Nathaniel Nucci

  • 910 Citations
  • 16 h-Index
20042020
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Personal profile

Research interests

Research Expertise:
NMR Spectroscopy | Reverse Micelle Technology | Protein Biophysics

Nuclear Magnetic Resonance (NMR) is a state-of-the-art spectroscopic method that provides both spatial and temporal information on the atomic level. This technology is especially insightful when examining macromolecules, but various technical challenges limit the size of the molecules that can be easily studied. I have unique expertise in the application of reverse micelle technology to the NMR-based investigation of macromolecular structure and dynamics. This special skill set allows my research group to ask a range of innovative questions about the ways biological systems function at the molecular level. In addition to NMR, we utilize UV/Visible absorption and fluorescence spectroscopy to investigate biomolecular structure and function. We are also developing an apparatus that combined fluorescence correlation microscopy with microfluidics to study chemical dynamics and the impacts of macromolecular crowding on protein function. Present projects include study of antifreeze protein function, nanoscale confinement effects on protein structure and function, structure/function studies of the hypoxia-inducible factor prolyl hydroxylases, and applications of reverse micelles such as drug delivery and manufacture of quantum dots.

Honors and Awards:  
New Jersey Health Foundation Research Grant 2016-2017

Member of:
American Association for the Advancement of Science
Biophysical Society
American Chemical Society

Education/Academic qualification

Doctor of Philosophy, doctorate, University of Pennsylvania

Fingerprint Dive into the research topics where Nathaniel Nucci is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Micelles Chemical Compounds
Water Chemical Compounds
Proteins Chemical Compounds
Biomolecular Nuclear Magnetic Resonance Medicine & Life Sciences
Viscosity Medicine & Life Sciences
Encapsulation Chemical Compounds
Nuclear magnetic resonance Chemical Compounds
Glycerol Chemical Compounds

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Projects 2016 2020

Research Output 2004 2018

  • 910 Citations
  • 16 h-Index
  • 22 Article
  • 2 Review article
  • 1 Letter
1 Citation (Scopus)

Toward comprehensive measurement of protein hydration dynamics: Facilitation of NMR-based methods by reverse micelle encapsulation

Gallo, P. N., Iovine, J. C. & Nucci, N., Sep 15 2018, In : Methods. 148, p. 146-153 8 p.

Research output: Contribution to journalReview article

Micelles
Encapsulation
Hydration
Nuclear magnetic resonance
Water

New insight on the S100A1-STIP1 complex highlights the important relationship between allostery and entropy in protein function

Nucci, N., Sep 1 2017, In : Biochemical Journal. 474, 17, p. 2977-2980 4 p.

Research output: Contribution to journalReview article

Phosphoproteins
Entropy
Calcium Signaling
S100 Proteins
Proteins
28 Citations (Scopus)

Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

O'Brien, E. S., Nucci, N., Fuglestad, B., Tommos, C. & Wand, A. J., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30879-30887 9 p.

Research output: Contribution to journalArticle

Cardiolipins
Cytochromes c
Apoptosis
Protein Unfolding
Micelles
3 Citations (Scopus)
Protein Unfolding
Bacteriophage T4
Protein Stability
Muramidase
Pressure
22 Citations (Scopus)

High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids

Nucci, N., Valentine, K. G. & Wand, A. J., Jan 1 2014, In : Journal of Magnetic Resonance. 241, 1, p. 137-147 11 p.

Research output: Contribution to journalArticle

Biomolecular Nuclear Magnetic Resonance
Macromolecules
macromolecules
Viscosity
Nuclear magnetic resonance spectroscopy