Projects per year
Personal profile
Research interests
Research Expertise:
NMR Spectroscopy | Reverse Micelle Technology | Protein Biophysics
Nuclear Magnetic Resonance (NMR) is a state-of-the-art spectroscopic method that provides both spatial and temporal information on the atomic level. This technology is especially insightful when examining macromolecules, but various technical challenges limit the size of the molecules that can be easily studied. I have unique expertise in the application of reverse micelle technology to the NMR-based investigation of macromolecular structure and dynamics. This special skill set allows my research group to ask a range of innovative questions about the ways biological systems function at the molecular level. In addition to NMR, we utilize UV/Visible absorption and fluorescence spectroscopy to investigate biomolecular structure and function. We are also developing an apparatus that combined fluorescence correlation microscopy with microfluidics to study chemical dynamics and the impacts of macromolecular crowding on protein function. Present projects include study of antifreeze protein function, nanoscale confinement effects on protein structure and function, structure/function studies of the hypoxia-inducible factor prolyl hydroxylases, and applications of reverse micelles such as drug delivery and manufacture of quantum dots.
Honors and Awards:
New Jersey Health Foundation Research Grant 2016-2017
Member of:
American Association for the Advancement of Science
Biophysical Society
American Chemical Society
Education/Academic qualification
Doctor of Philosophy, doctorate, University of Pennsylvania
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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U-RISE at Rowan University
Nucci, N. (PI)
National Institutes of Health (NIH)
4/1/21 → 3/31/26
Project: Other project
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CAREER:Experimental Studies of Protein Thermodynamics Facilitated by NMR with Reverse Micelles
Nucci, N. (PI)
National Science Foundation (NSF)
1/1/20 → 6/30/25
Project: Other project
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Measurement and Control of Exchange Processes in Reverse Micelle Systems
Nucci, N. (PI)
American Chemical Society- Petroleum Research Fund (ACS PRF)
7/1/20 → 8/31/24
Project: Other project
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Optimization and characterization of a novel matrix for delivery of small molecule, carbohydrate, and protein-based therapeutics.
Nucci, N. (PI)
New Jersey Health Foundation, Inc.
3/1/18 → 2/28/20
Project: Other project
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Characterization of 10MAG/LDAO reverse micelles: Understanding versatility for protein encapsulation
Stackhouse, C. I., Pierson, K. N., Labrecque, C. L., Mawson, C., Berg, J., Fuglestad, B. & Nucci, N. V., Aug 2024, In: Biophysical Chemistry. 311, 107269.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System
Sanders, A. B., Zangaro, J. T., Webber, N. K., Calhoun, R. P., Richards, E. A., Ricci, S. L., Work, H. M., Yang, D. D., Casey, K. R., Iovine, J. C., Baker, G., Douglas, T. V., Dutko, S. B., Fasano, T. J., Lofland, S. A., Rajan, A. A., Vasile, M. A., Carone, B. R. & Nucci, N. V., Mar 1 2022, In: Molecules. 27, 5, 1572.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Protein conformational entropy is not slaved to water
Marques, B. S., Stetz, M. A., Jorge, C., Valentine, K. G., Wand, A. J. & Nucci, N. V., Dec 1 2020, In: Scientific Reports. 10, 1, 17587.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Toward comprehensive measurement of protein hydration dynamics: Facilitation of NMR-based methods by reverse micelle encapsulation
Gallo, P. N., Iovine, J. C. & Nucci, N. V., Sep 15 2018, In: Methods. 148, p. 146-153 8 p.Research output: Contribution to journal › Review article › peer-review
11 Scopus citations -
New insight on the S100A1-STIP1 complex highlights the important relationship between allostery and entropy in protein function
Nucci, N. V., Sep 1 2017, In: Biochemical Journal. 474, 17, p. 2977-2980 4 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations