Nathaniel Nucci

  • 1050 Citations
  • 16 h-Index
20042020

Research output per year

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Personal profile

Research interests

Research Expertise:
NMR Spectroscopy | Reverse Micelle Technology | Protein Biophysics

Nuclear Magnetic Resonance (NMR) is a state-of-the-art spectroscopic method that provides both spatial and temporal information on the atomic level. This technology is especially insightful when examining macromolecules, but various technical challenges limit the size of the molecules that can be easily studied. I have unique expertise in the application of reverse micelle technology to the NMR-based investigation of macromolecular structure and dynamics. This special skill set allows my research group to ask a range of innovative questions about the ways biological systems function at the molecular level. In addition to NMR, we utilize UV/Visible absorption and fluorescence spectroscopy to investigate biomolecular structure and function. We are also developing an apparatus that combined fluorescence correlation microscopy with microfluidics to study chemical dynamics and the impacts of macromolecular crowding on protein function. Present projects include study of antifreeze protein function, nanoscale confinement effects on protein structure and function, structure/function studies of the hypoxia-inducible factor prolyl hydroxylases, and applications of reverse micelles such as drug delivery and manufacture of quantum dots.

Honors and Awards:  
New Jersey Health Foundation Research Grant 2016-2017

Member of:
American Association for the Advancement of Science
Biophysical Society
American Chemical Society

Education/Academic qualification

Doctor of Philosophy, doctorate, University of Pennsylvania

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Projects

Research Output

  • 1050 Citations
  • 16 h-Index
  • 22 Article
  • 2 Review article
  • 1 Letter

Toward comprehensive measurement of protein hydration dynamics: Facilitation of NMR-based methods by reverse micelle encapsulation

Gallo, P. N., Iovine, J. C. & Nucci, N., Sep 15 2018, In : Methods. 148, p. 146-153 8 p.

Research output: Contribution to journalReview article

  • 6 Scopus citations

    New insight on the S100A1-STIP1 complex highlights the important relationship between allostery and entropy in protein function

    Nucci, N., Sep 1 2017, In : Biochemical Journal. 474, 17, p. 2977-2980 4 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

    O'Brien, E. S., Nucci, N. V., Fuglestad, B., Tommos, C. & Wand, A. J., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30879-30887 9 p.

    Research output: Contribution to journalArticle

  • 37 Scopus citations

    High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids

    Nucci, N. V., Valentine, K. G. & Wand, A. J., Apr 2014, In : Journal of Magnetic Resonance. 241, 1, p. 137-147 11 p.

    Research output: Contribution to journalArticle

  • 31 Scopus citations