Michael O'Leary

  • 1197 Citations
  • 23 h-Index
1982 …2018
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Research Output 1982 2018

  • 1197 Citations
  • 23 h-Index
  • 32 Article
  • 2 Review article
  • 1 Chapter
2018
3 Citations (Scopus)

Mechanisms of drug binding to voltage-gated sodium channels

O'Leary, M. & Chahine, M., Jan 1 2018, Handbook of Experimental Pharmacology. Springer New York LLC, p. 209-231 23 p. (Handbook of Experimental Pharmacology; vol. 246).

Research output: Chapter in Book/Report/Conference proceedingChapter

Voltage-Gated Sodium Channels
Permeation
Electric potential
Channelopathies
Pharmaceutical Preparations
2017
7 Citations (Scopus)

Animal models of rheumatoid pain: Experimental systems and insights

Fischer, B. D., Adeyemo, A., O'Leary, M. & Bottaro, A., Jun 30 2017, In : Arthritis Research and Therapy. 19, 1, 146.

Research output: Contribution to journalReview article

Chronic Pain
Arthritis
Animal Models
Pain
Spondylarthropathies
12 Citations (Scopus)
Sodium Channels
Electrophysiology
Hyperalgesia
Spinal Ganglia
Up-Regulation
2015
20 Citations (Scopus)

Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury

Ritter, D. M., Zemel, B. M., Hala, T. J., O'Leary, M. E., Lepore, A. C. & Covarrubias, M., Jan 21 2015, In : Journal of Neuroscience. 35, 3, p. 1260-1273 14 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Spinal Cord Injuries
Neurons
Laminectomy
Protein Kinase C
2 Citations (Scopus)

MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels

O'leary, M. E. & Chahine, M., Jan 1 2015, In : Frontiers in Pharmacology. 6, MAY, 118.

Research output: Contribution to journalArticle

Sodium Channels
Cysteine
S 6
methanethiosulfonate
Pharmacology
2014
2 Citations (Scopus)

Modulation of peripheral Na+ channels and neuronal firing by n-butyl-p-aminobenzoate

Thériault, O., Poulin, H., Sculptoreanu, A., De Groat, W. C., O'Leary, M. E. & Chahine, M., Mar 15 2014, In : European Journal of Pharmacology. 727, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

para-Aminobenzoates
Spinal Ganglia
HEK293 Cells
Motor Neurons
Local Anesthetics
28 Citations (Scopus)

Regulation/modulation of sensory neuron sodium channels

Chahine, M. & O'Leary, M., Jan 1 2014, In : Handbook of Experimental Pharmacology. 221, p. 111-135 25 p.

Research output: Contribution to journalArticle

Sodium Channels
Tetrodotoxin
Sensory Receptor Cells
Neurons
Modulation
2012
22 Citations (Scopus)

Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons

Ho, C., Zhao, J., Malinowski, S., Chahine, M. & O'Leary, M. E., Apr 27 2012, In : Journal of Biological Chemistry. 287, 18, p. 15044-15053 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Spinal Ganglia
Sensory Receptor Cells
Neurons
Tetrodotoxin
28 Citations (Scopus)

Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons

Ritter, D. M., Ho, C., O'Leary, M. & Covarrubias, M., Jan 1 2012, In : Journal of Physiology. 590, 1, p. 145-161 17 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Protein Kinase C
Action Potentials
Neurons
G-Protein-Coupled Receptors
2011
35 Citations (Scopus)

Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits

Zhao, J., O'Leary, M. & Chahine, M., Aug 1 2011, In : Journal of Neurophysiology. 106, 2, p. 608-619 12 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Peripheral Nerves
Neurons
Cell Count
Polymerase Chain Reaction
29 Citations (Scopus)

Regulatory role of voltage-gated Na+ channel β subunits in sensory neurons

Chahine, M. & O'Leary, M. E., Dec 1 2011, In : Frontiers in Pharmacology. 2 NOV, Article 70.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Ions
Voltage-Gated Sodium Channels
Neurotoxins
Neuralgia
91 Citations (Scopus)

Single-cell analysis of sodium channel expression in dorsal root ganglion neurons

Ho, C. & O'Leary, M. E., Jan 1 2011, In : Molecular and Cellular Neuroscience. 46, 1, p. 159-166 8 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Sodium Channels
Spinal Ganglia
Neurons
Peripherins
34 Citations (Scopus)

Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels

Huang, H., Priori, S. G., Napolitano, C., O'Leary, M. & Chahine, M., Jan 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 1

Research output: Contribution to journalArticle

Mutation
Torsades de Pointes
Anti-Arrhythmia Agents
Patch-Clamp Techniques
Cysteine
2010
47 Citations (Scopus)

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias

O'Leary, M. & Hancox, J. C., May 1 2010, In : British Journal of Clinical Pharmacology. 69, 5, p. 427-442 16 p.

Research output: Contribution to journalReview article

Voltage-Gated Sodium Channels
Voltage-Gated Potassium Channels
Calcium Channels
Cocaine
Cardiac Arrhythmias
2007
18 Citations (Scopus)

Lidocaine promotes the trafficking and functional expression of Na v1.8 sodium channels in mammalian cells

Zhao, J., Ziane, R., Chatelier, A., O'Leary, M. E. & Chahine, M., Jul 1 2007, In : Journal of Neurophysiology. 98, 1, p. 467-477 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Lidocaine
Spinal Ganglia
Cultured Cells
Immunochemistry
2005
34 Citations (Scopus)

Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben

Winkelman, D. L. B., Beck, C. L., Ypey, D. L. & O'Leary, M., Sep 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 314, 3, p. 1177-1186 10 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Anesthetics
Neurons
para-Aminobenzoates
S 6
2004
70 Citations (Scopus)

State-dependent trapping of flecainide in the cardiac sodium channel

Ramos, E. & O'Leary, M., Oct 1 2004, In : Journal of Physiology. 560, 1, p. 37-49 13 p.

Research output: Contribution to journalArticle

Flecainide
Sodium Channels
Inhibitory Concentration 50
Mutation
Isoleucine
2003
12 Citations (Scopus)

Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms

O'Leary, M., Digregorio, M. & Chahine, M., Dec 1 2003, In : Molecular Pharmacology. 64, 6, p. 1575-1585 11 p.

Research output: Contribution to journalArticle

Sodium Channels
Mutation
cocaethylene
Isoleucine
Xenopus laevis
34 Citations (Scopus)

Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain

Beekwilder, J. P., O'Leary, M. E., Van Den Broek, L. P., Van Kempen, G. T. H., Ypey, D. L. & Van Den Berg, R. J., Feb 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 2, p. 531-538 8 p.

Research output: Contribution to journalArticle

para-Aminobenzoates
Spinal Ganglia
Chronic Pain
Anesthetics
Neurons
2002
46 Citations (Scopus)

Cocaine binds to a common site on open and inactivated human heart (Na v 1.5) sodium channels

O'Leary, M. & Chahine, M., Jun 15 2002, In : Journal of Physiology. 541, 3, p. 701-716 16 p.

Research output: Contribution to journalArticle

Sodium Channels
Cocaine
Mutation
Xenopus
Pharmaceutical Preparations
36 Citations (Scopus)

Inhibition of HERG potassium channels by cocaethylene: A metabolite of cocaine and ethanol

O'Leary, M., Jan 10 2002, In : Cardiovascular Research. 53, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Potassium Channels
Cocaine
Ethanol
Delayed Rectifier Potassium Channels
Alcohols
2001
72 Citations (Scopus)

Gating properties of Nav1.7 and Nav1.8 peripheral nerve sodium channels

Vijayaragavan, K., O'Leary, M. & Chahine, M., Oct 15 2001, In : Journal of Neuroscience. 21, 20, p. 7909-7918 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Peripheral Nerves
Spinal Ganglia
Neurons
Xenopus
36 Citations (Scopus)

Inhibition of human ether-a-go-go potassium channels by cocaine

O'Leary, M., Jan 1 2001, In : Molecular Pharmacology. 59, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

Potassium Channels
Cocaine
Ether
Cardiotonic Agents
Patch-Clamp Techniques
1998
39 Citations (Scopus)
Sodium Channels
Protein Isoforms
Muscles
Patch-Clamp Techniques
Cultured Cells
1995
54 Citations (Scopus)

A molecular link between activation and inactivation of sodium channels

O’leary, M. E., Chen, L. Q., Kallen, R. G. & Horn, R., Oct 1 1995, In : Journal of General Physiology. 106, 4, p. 641-658 18 p.

Research output: Contribution to journalArticle

Sodium Channels
Tyrosine
Glutamine
Phenylalanine
1994
50 Citations (Scopus)

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor

O'Leary, M., Filatov, G. N. & White, M. M., Jan 1 1994, In : American Journal of Physiology - Cell Physiology. 266, 3 35-3

Research output: Contribution to journalArticle

Curare
Torpedo
Tubocurarine
Cholinergic Receptors
Binding Sites

Characterization of d-tubocurarine binding site of Torpedo acetylcholine receptor

O'Leary, M., Filatov, G. N. & White, M. M., Jan 1 1994, In : AM.J.PHYSIOL.. 266, 3 part 1

Research output: Contribution to journalArticle

Torpedo
cholinergic receptors
binding sites
25 Citations (Scopus)

Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels

O’Leary, M. E., Kallen, R. G. & Horn, R., Sep 1 1994, In : Journal of General Physiology. 104, 3, p. 523-539 17 p.

Research output: Contribution to journalArticle

Sodium Channels
Cations
Binding Sites
tetrapentylammonium
Horns
43 Citations (Scopus)

Internal block of human heart sodium channels by symmetrical tetra-alkylammoniums

O’Leary, M. E. & Horn, R., Sep 1 1994, In : Journal of General Physiology. 104, 3, p. 507-522 16 p.

Research output: Contribution to journalArticle

Heart Block
Tetraethylammonium
Sodium Channels
Membranes
Ion Transport
1992
81 Citations (Scopus)

Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor

O'Leary, M. E. & White, M. M., Jan 1 1992, In : Journal of Biological Chemistry. 267, 12, p. 8360-8365 6 p.

Research output: Contribution to journalArticle

Torpedo
Cholinergic Receptors
Chemical activation
Ligands
Mutation
1989
8 Citations (Scopus)

Batrachotoxin and α-scorpion toxin stabilize the open state of single voltage-gated sodium channels

O'Leary, M. & Krueger, B. K., Dec 22 1989, In : Molecular Pharmacology. 36, 5, p. 789-795 7 p.

Research output: Contribution to journalArticle

Batrachotoxins
Voltage-Gated Sodium Channels
Scorpions
Venoms
Saxitoxin
1986
93 Citations (Scopus)

Presynaptic calcium channels in rat cortical synaptosomes: Fast-kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors

Suszkiw, J. B., O'Leary, M., Murawsky, M. M. & Wang, T., Jan 1 1986, In : Journal of Neuroscience. 6, 5, p. 1349-1357 9 p.

Research output: Contribution to journalArticle

Inbred Strains Rats
Nitrendipine
Drug Receptors
Synaptosomes
Calcium Channels
1983
19 Citations (Scopus)

Effect of Colchicine on 45Ca and Choline Uptake, and Acetylcholine Release in Rat Brain Synaptosomes

O'Leary, M. & Suszkiw, J. B., Jan 1 1983, In : Journal of Neurochemistry. 40, 4, p. 1192-1195 4 p.

Research output: Contribution to journalArticle

Synaptosomes
Colchicine
Choline
Acetylcholine
Rats
37 Citations (Scopus)
Synaptosomes
Acetylcholine
Rats
Transmitters
Brain
1982
30 Citations (Scopus)
Synaptosomes
Labeling
Acetylcholine
Rats
Brain