Mary Alpaugh

Department Chair, Associate Professor

Former affiliation
  • 1392 Citations
  • 17 h-Index
19942019
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Personal profile

Research interests

Research Expertise:
Cancer Biology | Tumor Progression | Metastasis | Intravasation

My research focuses predominantly on the molecular mechanisms of intravasation, the rate-limiting step of metastasis, and resistance/susceptibility of lymphovascular emboli to therapeutics.

Metastasis poses the single most difficult clinical challenge in the attempt to manage and treat cancer. In this effort, I have established patient-derived xenografts, signifcantly the first (and only) human transplantable inflammatory breast cancer xenograft, called MARY-X. Inflammatory breast cancer (IBC) is one of the most aggressive types of breast cancer; nearly 100% of all women with IBC have lymph node involvement and 25% have distant metastases upon diagnosis. The signature phenotype of IBC is florid lymphovascular invasion of cancer emboli. Whereas most human xenografts grow as a subcutaneous confluent cellular mass, MARY-X grows exclusively in the murine lymphatic and blood vessels, recapitulating the phenotype displayed in human IBC and in essence providing both a preclinical IBC model and a relevant model of metastasis. MARY-X, in vitro, is a primary cellular derivative from tumor explants. These tumor cells spontaneously form tight, compact aggregates of cells termed “MARY-X spheroids”. Comparable to human IBC emboli, a persistent, over-expression of an intact E-cadherin/α, β-catenin axis mediates the compaction of both in vitro and in vivo MARY-X spheroids and tumor emboli, respectively. The in vitro MARY-X spheroid has comparative 3-dimensional (3-D) architectural/pathophysiological features to the lymphovascular embolus. Therefore MARY-X provides a relevant 3D in vitro analysis platform for drug design and development of IBC and metastatic disease i.e. the lymphovascular embolus.

Member of:
American Association for Cancer Research

Education/Academic qualification

Biochemistry, doctorate, University of Houston

Bachelor of Science, Bachelor

Fingerprint Dive into the research topics where Mary Alpaugh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Inflammatory Breast Neoplasms Medicine & Life Sciences
Embolism Medicine & Life Sciences
Cadherins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Heterografts Medicine & Life Sciences
Neoplasm Metastasis Medicine & Life Sciences
Phenotype Medicine & Life Sciences

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Projects 2016 2018

Research Output 1994 2019

  • 1392 Citations
  • 17 h-Index
  • 28 Article
  • 1 Comment/debate
  • 1 Letter
  • 1 Review article

Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes

Chantarasriwong, O., Dorwart, T. J., Morales, T. H., Maggio, S. F., Settle, A. L., Milcarek, A. T., Alpaugh, M. L., Theodoraki, M. A. & Theodorakis, E. A., Dec 2019, In : Bioorganic Chemistry. 93, 103303.

Research output: Contribution to journalArticle

Garcinia
Enantiomers
Biological Products
Cells
Xanthones

Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’

Alvarez, M. J., Yan, P., Alpaugh, M. L., Bowden, M., Sicinska, E., Zhou, C. W., Karan, C., Realubit, R. B., Mundi, P. S., Grunn, A., Jäger, D., Chabot, J. A., Fojo, A. T., Oberstein, P. E., Hibshoosh, H., Milsom, J. W., Kulke, M. H., Loda, M., Chiosis, G., Reidy-Lagunes, D. L. & 1 others, Califano, A., Oct 1 2019, In : Nature Genetics. 51, 10, p. 1427-1428 2 p.

Research output: Contribution to journalLetter

Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer

Chantarasriwong, O., Milcarek, A. T., Morales, T. H., Settle, A. L., Rezende, C. O., Althufairi, B. D., Theodoraki, M. A., Alpaugh, M. & Theodorakis, E. A., Apr 15 2019, In : European Journal of Medicinal Chemistry. 168, p. 405-413 9 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Xanthones
Pharmacodynamics
Structure-Activity Relationship
Cytotoxicity
1 Citation (Scopus)

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Kishinevsky, S., Wang, T., Rodina, A., Chung, S. Y., Xu, C., Philip, J., Taldone, T., Joshi, S., Alpaugh, M., Bolaender, A., Gutbier, S., Sandhu, D., Fattahi, F., Zimmer, B., Shah, S. K., Chang, E., Inda, C., Koren, J., Saurat, N. G., Leist, M. & 9 others, Gross, S. S., Seshan, V. E., Klein, C., Tomishima, M. J., Erdjument-Bromage, H., Neubert, T. A., Henrickson, R. C., Chiosis, G. & Studer, L., Dec 1 2018, In : Nature communications. 9, 1, 4345.

Research output: Contribution to journalArticle

Parkinson disease
dopamine
Dopaminergic Neurons
Biosensing Techniques
Mesencephalon
1 Citation (Scopus)

Erratum: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers[Breast Cancer Res,17 (2015)(149)] DOI:10.1186/s13058-015-0658-0

Putcha, P., Yu, J., Rodriguez-Barrueco, R., Saucedo-Cuevas, L., Villagrasa, P., Murga-Penas, E., Quayle, S. N., Yang, M., Castro, V., Llobet-Navas, D., Birnbaum, D., Finetti, P., Woodward, W. A., Bertucci, F., Alpaugh, M., Califano, A. & Silva, J., Apr 19 2017, In : Breast Cancer Research. 19, 1, 49.

Research output: Contribution to journalComment/debate

Inflammatory Breast Neoplasms
Publications
Breast Neoplasms