Lark Perez

  • 532 Citations
  • 12 h-Index
20032020

Research output per year

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Personal profile

Research interests

Research Expertise: 
Chemical Biology | Organic Synthesis | Medicinal Chemistry

The goal of my research is to apply synthetic organic chemistry to enhance the understanding of biological processes, especially cellular signaling. Applications of this general research focus include the study of bacterial quorum sensing, a process in which bacteria regulate gene expression, including virulence factors, through the synthesis and detection of small molecule signals and a major research focus of my group. The group’s research in this area has led to the identification of several highly potent and drug-like inhibitors of bacterial virulence in gram-negative bacteria and has illuminated aspects of the biological regulatory circuits involved. We are fully equipped and experienced in chemical synthesis, medicinal chemistry and microbiology.

Member of:
American Chemical Society (ACS)
American Society of Microbiology (ASM)

Education/Academic qualification

Doctor of Philosophy, doctorate, Yale University

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Projects

Research Output

  • 532 Citations
  • 12 h-Index
  • 17 Article

Parallel quorum-sensing system in Vibrio cholerae prevents signal interference inside the host

Watve, S., Barrasso, K., Jung, S. A., Davis, K. J., Hawver, L. A., Khataokar, A., Palaganas, R. G., Neiditch, M. B., Perez, L. J. & Ng, W. L., Jan 1 2020, In : PLoS Pathogens. 16, 2, e1008313.

Research output: Contribution to journalArticle

Open Access
  • Inhibition of pseudomonas aeruginosa biofilm formation with surface modified polymeric nanoparticles

    Flockton, T. R., Schnorbus, L., Araujo, A., Adams, J., Hammel, M. & Perez, L. J., Jun 2019, In : Pathogens. 8, 2, 55.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor

    Capilato, J. N., Philippi, S. V., Reardon, T., McConnell, A., Oliver, D. C., Warren, A., Adams, J. S., Wu, C. & Perez, L. J., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 1, p. 153-165 13 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition

    Wu, B., Capilato, J., Pham, M. P., Walker, J., Spur, B., Rodriguez, A., Perez, L. J. & Yin, K., Jun 2016, In : FASEB Journal. 30, 6, p. 2400-2410 11 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

    Lu, H. D., Spiegel, A. C., Hurley, A., Perez, L. J., Maisel, K., Ensign, L. M., Hanes, J., Bassler, B. L., Semmelhack, M. F. & Prud'Homme, R. K., Apr 8 2015, In : Nano Letters. 15, 4, p. 2235-2241 7 p.

    Research output: Contribution to journalArticle

  • 32 Scopus citations