Lark Perez

  • 477 Citations
  • 12 h-Index
20032020
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Personal profile

Research interests

Research Expertise: 
Chemical Biology | Organic Synthesis | Medicinal Chemistry

The goal of my research is to apply synthetic organic chemistry to enhance the understanding of biological processes, especially cellular signaling. Applications of this general research focus include the study of bacterial quorum sensing, a process in which bacteria regulate gene expression, including virulence factors, through the synthesis and detection of small molecule signals and a major research focus of my group. The group’s research in this area has led to the identification of several highly potent and drug-like inhibitors of bacterial virulence in gram-negative bacteria and has illuminated aspects of the biological regulatory circuits involved. We are fully equipped and experienced in chemical synthesis, medicinal chemistry and microbiology.

Member of:
American Chemical Society (ACS)
American Society of Microbiology (ASM)

Education/Academic qualification

Doctor of Philosophy, doctorate, Yale University

Fingerprint Dive into the research topics where Lark Perez is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Quorum Sensing Medicine & Life Sciences
Vibrio cholerae Medicine & Life Sciences
Computer aided instruction Chemical Compounds
Pseudomonas aeruginosa Medicine & Life Sciences
Molecules Chemical Compounds
Lead compounds Chemical Compounds
Vibrio Medicine & Life Sciences
Biofilms Medicine & Life Sciences

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Projects 2015 2020

Research Output 2003 2019

  • 477 Citations
  • 12 h-Index
  • 16 Article

Inhibition of pseudomonas aeruginosa biofilm formation with surface modified polymeric nanoparticles

Flockton, T. R., Schnorbus, L., Araujo, A., Adams, J., Hammel, M. & Perez, L. J., Jun 2019, In : Pathogens. 8, 2, 55.

Research output: Contribution to journalArticle

Open Access
Biofilms
Nanoparticles
Pseudomonas aeruginosa
Virulence Factors
Microbial Drug Resistance
8 Citations (Scopus)

Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor

Capilato, J. N., Philippi, S. V., Reardon, T., McConnell, A., Oliver, D. C., Warren, A., Adams, J. S., Wu, C. & Perez, L., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 1, p. 153-165 13 p.

Research output: Contribution to journalArticle

Quorum Sensing
Pseudomonas aeruginosa
Ligands
Pathogens
Structure-Activity Relationship
8 Citations (Scopus)

Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition

Wu, B., Capilato, J., Pham, M. P., Walker, J., Spur, B., Rodriguez, A., Perez, L. & Yin, K., Jun 1 2016, In : FASEB Journal. 30, 6, p. 2400-2410 11 p.

Research output: Contribution to journalArticle

Quorum Sensing
Pseudomonas aeruginosa
Virulence
Sepsis
Neutrophils
26 Citations (Scopus)

Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles

Lu, H. D., Spiegel, A. C., Hurley, A., Perez, L., Maisel, K., Ensign, L. M., Hanes, J., Bassler, B. L., Semmelhack, M. F. & Prud'Homme, R. K., Apr 8 2015, In : Nano Letters. 15, 4, p. 2235-2241 7 p.

Research output: Contribution to journalArticle

cholera
Computer aided instruction
Antibiotics
computer assisted instruction
communication
24 Citations (Scopus)

Potent irreversible inhibitors of LasR quorum sensing in Pseudomonas aeruginosa

O'Brien, K. T., Noto, J. G., Nichols-O'Neill, L. & Perez, L., Feb 12 2015, In : ACS Medicinal Chemistry Letters. 6, 2, p. 162-167 6 p.

Research output: Contribution to journalArticle

Pyocyanine
Lead compounds
Quorum Sensing
Biofilms
Virulence Factors