Ileana Soto Reyes

Former affiliation
  • 1832 Citations
  • 20 h-Index

Research output per year

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Personal profile

Research interests

Research Expertise: 
Neurodegeneration | Mouse Genetics | Neuroinflammation

My primary research focus is on the role of inflammation in neurodegenerative diseases such as Niemann Pick Type-C disease. In particular, emerging evidence suggests that neuroinflammation, a carefully controlled infiltration of specific immune cells into the tissue, may be critical for neuronal damage. The interplay between neurons, resident support, endothelial cell and infiltrating immune cells (particularly monocytes) is complex. Therefore I will apply cellular and genetic approaches to critically assess the role of the different cell types in neurodegenerative diseases.

Honors and Awards:
The Jackson Laboratory Postdoctoral Fellowship, NIH T32 training grant, 2009-2011

Member of:
Society for Neuroscience (
American Society for Cell Biology (ASCB)

Education/Academic qualification

Doctor of Philosophy, doctorate

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Research Output

  • 1832 Citations
  • 20 h-Index
  • 31 Article
  • 2 Review article

Deficiency of complement component c1q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

Graham, L. C., Kocalis, H. E., Soto, I. & Howell, G. R., May 1 2020, In : eNeuro. 7, 3, p. 1-12 12 p., ENEURO.0057-20.2020.

Research output: Contribution to journalArticle

Open Access
  • NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C

    Boyle, B. R., Melli, S. E., Altreche, R. S., Padron, Z. M., Yousufzai, F. A. K., Kim, S., Vasquez, M. D., Carone, D. M., Carone, B. R. & Soto, I., Aug 3 2020, In : Development (Cambridge). 147, 21

    Research output: Contribution to journalArticle

    Open Access
  • Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

    Onos, K. D., Uyar, A., Keezer, K. J., Jackson, H. M., Preuss, C., Acklin, C. J., O’Rourke, R., Buchanan, R., Cossette, T. L., Sukoff Rizzo, S. J., Soto, I., Carter, G. W. & Howell, G. R., May 2019, In : PLoS Genetics. 15, 5, e1008155.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations

    Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

    Kavetsky, L., Green, K. K., Boyle, B. R., Yousufzai, F. A. K., Padron, Z. M., Melli, S. E., Kuhnel, V. L., Jackson, H. M., Blanco, R. E., Howell, G. R. & Soto, I., Dec 1 2019, In : Scientific Reports. 9, 1, 14722.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Meox2 haploinsufficiency accelerates axonal degeneration in DBA/2J glaucoma

    Buchanan, R. A., Foley, K. E., Pepper, K. W., Reagan, A. M., Keezer, K. J., Hewes, A. A., Diemler, C. A., Preuss, C., Soto, I., John, S. W. M. & Howell, G. R., Aug 2019, In : Investigative Ophthalmology and Visual Science. 60, 10, p. 3283-3296 14 p.

    Research output: Contribution to journalArticle

    Open Access