Ileana Soto Reyes

Former affiliation
  • 1525 Citations
  • 19 h-Index
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Personal profile

Research interests

Research Expertise: 
Neurodegeneration | Mouse Genetics | Neuroinflammation

My primary research focus is on the role of inflammation in neurodegenerative diseases such as Niemann Pick Type-C disease. In particular, emerging evidence suggests that neuroinflammation, a carefully controlled infiltration of specific immune cells into the tissue, may be critical for neuronal damage. The interplay between neurons, resident support, endothelial cell and infiltrating immune cells (particularly monocytes) is complex. Therefore I will apply cellular and genetic approaches to critically assess the role of the different cell types in neurodegenerative diseases.

Honors and Awards:
The Jackson Laboratory Postdoctoral Fellowship, NIH T32 training grant, 2009-2011

Member of:
Society for Neuroscience (
American Society for Cell Biology (ASCB)

Education/Academic qualification

Doctor of Philosophy, doctorate

Fingerprint Dive into the research topics where Ileana Soto Reyes is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Glaucoma Medicine & Life Sciences
Retinal Ganglion Cells Medicine & Life Sciences
Optic Nerve Medicine & Life Sciences
Inbred DBA Mouse Medicine & Life Sciences
Axons Medicine & Life Sciences
Optic Disk Medicine & Life Sciences
Axotomy Medicine & Life Sciences
Fibroblast Growth Factor 2 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2019

  • 1525 Citations
  • 19 h-Index
  • 29 Article
  • 2 Review article

Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

Onos, K. D., Uyar, A., Keezer, K. J., Jackson, H. M., Preuss, C., Acklin, C. J., O’Rourke, R., Buchanan, R., Cossette, T. L., Sukoff Rizzo, S. J., Soto, I., Carter, G. W. & Howell, G. R., May 2019, In : PLoS Genetics. 15, 5, e1008155.

Research output: Contribution to journalArticle

Open Access
Alzheimer disease
Reproducibility of Results
genetic variation
Alzheimer Disease
animal models

Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

Kavetsky, L., Green, K. K., Boyle, B. R., Yousufzai, F. A. K., Padron, Z. M., Melli, S. E., Kuhnel, V. L., Jackson, H. M., Blanco, R. E., Howell, G. R. & Soto, I., Dec 1 2019, In : Scientific Reports. 9, 1, 14722.

Research output: Contribution to journalArticle

Open Access
Purkinje Cells
Type C Niemann-Pick Disease

Meox2 haploinsufficiency accelerates axonal degeneration in DBA/2J glaucoma

Buchanan, R. A., Foley, K. E., Pepper, K. W., Reagan, A. M., Keezer, K. J., Hewes, A. A., Diemler, C. A., Preuss, C., Soto Reyes, I., John, S. W. M. & Howell, G. R., Aug 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 10, p. 3283-3296 14 p.

Research output: Contribution to journalArticle

Open Access
Homeobox Genes
Inbred DBA Mouse

Vascular Inflammation Risk Factors in Retinal Disease

Soto, I., Krebs, M. P., Reagan, A. M. & Howell, G. R., Sep 15 2019, In : Annual Review of Vision Science. 5, p. 99-122 24 p.

Research output: Contribution to journalArticle

Retinal Diseases
Blood Vessels
Macular Degeneration
Diabetic Retinopathy

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice

Harder, J. M., Williams, P. A., Soto, I., Foxworth, N. E., Fernandes, K. A., Freeburg, N. F., Libby, R. T. & John, S. W. M., Jun 1 2018, In : Cell Death and Disease. 9, 6, 705.

Research output: Contribution to journalArticle

Inbred DBA Mouse
Retinal Ganglion Cells
Optic Nerve Injuries
Cell Death