Projects per year
Personal profile
Research interests
Research Expertise:
Drug Discovery | Reaction Invention | Organic Synthesis
My background is in synthetic organic chemistry with an emphasis in methods development and library synthesis. My research group is focused on developing novel reactions for the synthesis of biologically relevant molecular scaffolds. Our central hypothesis is to invent organic reactions to access biologically relevant molecular targets. Thus, I have a number of projects dedicated to the synthesis of small molecule libraries with a diverse array of biological properties and to the discovery of novel reaction pathways for the synthesis of complex molecular scaffolds.
Projects:
Novel Methods for the Synthesis of Small Heterocycles, Synthesis of Pharmacologically Relevant Molecular Scaffolds, Photoredox Catalysis for New Reaction Discovery, Isolation and Characterization of Natural Products from Peruvian Medicinal Plants, Development of Novel Drugs for the Treatment of Diabetes and Cardiovascular Diseases, Novel Alkaloid-like Scaffolds as Highly Potent Analgesics Without side Effects.
Award:
2018 NSF CAREER: The Faculty Early Career Development (CAREER) Program Award
Member of:
American Chemical Society Division of Organic Chemistry (ACS)
Recent Academic Projects:
Developing workshop-like certificate program for returning veterans in chemistry instrumentation.
Education/Academic qualification
Doctor of Philosophy, doctorate
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Projects
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Metallooxaziridines for the Synthesis of Nitrogen-Containing Three-Membered Heterocycles
5/1/18 → 4/30/23
Project: Other project
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Indole Alkaloids from Peruvian Medicinal Plants for the Treatment of Malaria
7/30/16 → 9/30/18
Project: Other project
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Effects of heavy metal pollutants on the secondary metabolite content in Peruvian medicinal plants
10/1/14 → 9/30/17
Project: Research project
Research Output
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Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA
Islam, A., Rahman, M. A., Brenner, M. B., Moore, A., Kellmyer, A., Buechler, H. M., Digiorgio, F., Verchio, V. R., McCracken, L., Sumi, M., Hartley, R., Lizza, J. R., Moura-Letts, G., Fischer, B. D. & Keck, T. M., Oct 9 2020, In: ACS Pharmacology and Translational Science. 3, 5, p. 907-920 14 p.Research output: Contribution to journal › Article › peer-review
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From Heterocycles to Carbacycles: Synthesis of Carbocyclic Nucleoside Analogues from Enals and Hydroxylamines
Das, P., Almond, D. W., Tumbelty, L. N., Austin, B. E. & Moura-Letts, G., Jul 17 2020, In: Organic Letters. 22, 14, p. 5491-5495 5 p.Research output: Contribution to journal › Article › peer-review
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Synthesis of Chromenoisoxazolidines from Substituted Salicylic Nitrones via Visible-Light Photocatalysis
Haun, G., Paneque, A. N., Almond, D. W., Austin, B. E. & Moura-Letts, G., Mar 1 2019, In: Organic Letters. 21, 5, p. 1388-1392 5 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
One-pot synthesis of vinylisoxazolidines from simple hydroxylamines and conjugated carbonyls
Quinn, D. J., Tumbelty, L. N., Moscarello, E. M., Paneque, A. N., Zinsky, A. H., Russ, M. P., Haun, G. J., Cinti, N. A., Dare, R. M. & Moura-Letts, G., Dec 13 2017, In: Tetrahedron Letters. 58, 50, p. 4682-4686 5 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols
Lizza, J. R. & Moura-Letts, G., Mar 15 2017, In: Synthesis (Germany). 49, 6, p. 1231-1242 12 p., ss-2016-m0690-op.Research output: Contribution to journal › Article › peer-review
8 Scopus citations