Personal profile
Research interests
My research interests are in two major areas: designing/characterizing peptides with specific functions and antimicrobial surfaces.
The majority of the research focuses on the development and characterization of antimicrobial peptides. These are short, cationic sequences that are highly effective, broad spectrum antimicrobials with low toxicity profiles. I study the chemical and amino-acid composition of these peptides and the role different amino acids play in the functional properties of these peptides. My lab also has a project focused on the design of peptides to interact with optically active porphyrins toward the development of novel materials for application in photovoltaic devices.
I also am interested in antimicrobial thin film coatings. In collaboration with the Departments of Physics & Astronomy and Electrical & Computer Engineering, my team has developed a series of coatings (patent pending) with a variety of antimicrobial and physical properties. The group focuses on the efficacy and mechanism of the antimicrobial coatings.
Education/Academic qualification
Doctor of Philosophy, doctorate
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Collaborations and top research areas from the last five years
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Development of novel, daptomycin-inspired antimicrobial peptides using non-canonical amino acids
Caputo, G. (PI)
National Institutes of Health (NIH)
12/20/24 → 11/30/27
Project: Other project
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Antimicrobial and solubility investigation of coated materials
Caputo, G. (PI)
6/1/22 → 12/31/22
Project: Other project
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Metallic nanocluster structure fluctuations as an early detector of cancer biomarkers
Caputo, G. (PI)
Virginia Commonwealth University
7/1/20 → 6/30/23
Project: Other project
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Combinatorial Antimicrobial Effects of Imidazolium-Based Ionic Liquids and Antifungals on Model Fungal Organisms
Calixto, J. G., Fetz, P. R., Ammerman, D., Flores, Y. R., Caputo, G. A., Vaden, T. D. & Carone, B. R., Dec 2025, In: Biomolecules. 15, 12, 1657.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of the Ellman’s Reagent Protocol for Free Sulfhydryls Under Protein Denaturing Conditions
Ginet, S. R., Gonzalez, F., Marano, M. L., Salecha, M. D., Reiner, J. E. & Caputo, G. A., Jun 2025, In: Analytica. 6, 2, 18.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Lipid bilayer permeabilities and antibiotic effects of tetramethylguanidinium and choline fatty acid ionic liquids
Dutta, A., Burrell, B., Prajapati, E., Cottle, S., Maurer, H. Y., Urban, M. J., Pennock, S. R., Muhamed, A. M., Harris, J., Flores, Y., Staman, L., Carone, B. R., Caputo, G. A. & Vaden, T. D., Jan 2025, In: Biochimica et Biophysica Acta - Biomembranes. 1867, 1, 184393.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Silver (I) and Silver (II) Oxide Films for Biomedical Implants: Synthesis, Stability, Ion Release, and Antibacterial Efficacy
Akantibila, M., Maurer, H., Urban, M., DiSpirito, S., Torres, J., Muhamed, A., Harris, J., Bharath, A., Green, R., Scabarozi, T. H., Caputo, G. A., Carabetta, V. J. & Hettinger, J. D., Nov 2025, In: Journal of Biomedical Materials Research - Part A. 113, 11, e38006.Research output: Contribution to journal › Article › peer-review
Open Access -
Cluster-Enhanced Nanopore Sensing of Ovarian Cancer Marker Peptides in Urine
Rockett, T. W., Almahyawi, M., Ghimire, M. L., Jonnalagadda, A., Tagliaferro, V., Seashols-Williams, S. J., Bertino, M. F., Caputo, G. A. & Reiner, J. E., Feb 23 2024, In: ACS Sensors. 9, 2, p. 860-869 10 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Scopus citations