Gregory Caputo

Department Head, Associate Professor

  • 1379 Citations
  • 20 h-Index
20022019
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Personal profile

Research interests

My research interests are in two major areas: designing/characterizing peptides with specific functions and antimicrobial surfaces.

The majority of the research focuses on the development and characterization of antimicrobial peptides. These are short, cationic sequences that are highly effective, broad spectrum antimicrobials with low toxicity profiles. I study the chemical and amino-acid composition of these peptides and the role different amino acids play in the functional properties of these peptides. My lab also has a project focused on the design of peptides to interact with optically active porphyrins toward the development of novel materials for application in photovoltaic devices.

I also am interested in antimicrobial thin film coatings. In collaboration with the Departments of Physics & Astronomy and Electrical & Computer Engineering, my team has developed a series of coatings (patent pending) with a variety of antimicrobial and physical properties. The group focuses on the efficacy and mechanism of the antimicrobial coatings.

Education/Academic qualification

Doctor of Philosophy, doctorate

Fingerprint Dive into the research topics where Gregory Caputo is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Peptides Chemical Compounds
Ionic Liquids Chemical Compounds
Membranes Medicine & Life Sciences
Polymers Chemical Compounds
Fluorescence Medicine & Life Sciences
Lipid Bilayers Medicine & Life Sciences
Porphyrins Chemical Compounds
Myoglobin Chemical Compounds

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Research Output 2002 2019

  • 1379 Citations
  • 20 h-Index
  • 38 Article
  • 3 Chapter
  • 3 Review article
  • 1 innovation

Activity and characterization of a pH-sensitive antimicrobial peptide

Hitchner, M. A., Santiago-Ortiz, L. E., Necelis, M. R., Shirley, D. J., Palmer, T. J., Tarnawsky, K. E., Vaden, T. & Caputo, G., Oct 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 10, 182984.

Research output: Contribution to journalArticle

Peptides
Membranes
Assays
Agglomeration
Lipids

Analyzing Transmembrane Protein and Hydrophobic Helix Topography by Dual Fluorescence Quenching

Caputo, G. & London, E., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 351-368 18 p. (Methods in Molecular Biology; vol. 2003).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescence
Membranes
Membrane Proteins
Proteins
Lipid Bilayers

Characterization and antimicrobial activity of amphiphilic peptide ap3 and derivative sequences

Chrom, C. L., Renn, L. M. & Caputo, G., Mar 1 2019, In : Antibiotics. 8, 1, 20.

Research output: Contribution to journalArticle

Open Access
Derivatives
Peptides
Flounder
Assays
Fluorescence Spectrometry

Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells

Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Cytotoxicity
Membrane Lipids
Yeast
Permeability

Effects of ionic liquid alkyl chain length on denaturation of myoglobin by anionic, cationic, and zwitterionic detergents

Lee, J. Y., Selfridge, K. M., Kohn, E. M., Vaden, T. D. & Caputo, G. A., Jul 2019, In : Biomolecules. 9, 7, 264.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Denaturation
Myoglobin
Chain length
Detergents