Projects per year
Personal profile
Research interests
My research interests are in two major areas: designing/characterizing peptides with specific functions and antimicrobial surfaces.
The majority of the research focuses on the development and characterization of antimicrobial peptides. These are short, cationic sequences that are highly effective, broad spectrum antimicrobials with low toxicity profiles. I study the chemical and amino-acid composition of these peptides and the role different amino acids play in the functional properties of these peptides. My lab also has a project focused on the design of peptides to interact with optically active porphyrins toward the development of novel materials for application in photovoltaic devices.
I also am interested in antimicrobial thin film coatings. In collaboration with the Departments of Physics & Astronomy and Electrical & Computer Engineering, my team has developed a series of coatings (patent pending) with a variety of antimicrobial and physical properties. The group focuses on the efficacy and mechanism of the antimicrobial coatings.
Education/Academic qualification
Doctor of Philosophy, doctorate
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Projects
- 1 Active
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Metallic nanocluster structure fluctuations as an early detector of cancer biomarkers
Virginia Commonwealth University
7/1/20 → 6/30/23
Project: Other project
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Amphiphilic polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria
Takahashi, H., Caputo, G. A. & Kuroda, K., Apr 21 2021, In: Biomaterials Science. 9, 8, p. 2758-2767 10 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Beneficial impacts of incorporating the non‐natural amino acid azulenyl‐alanine into the Trp‐rich antimicrobial peptide buCATHL4B
D’souza, A. R., Necelis, M. R., Kulesha, A., Caputo, G. A. & Makhlynets, O. V., Mar 2021, In: Biomolecules. 11, 3, p. 1-18 18 p., 421.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G
Hitchner, M. A., Necelis, M. R., Shirley, D. & Caputo, G. A., Apr 2021, In: Probiotics and Antimicrobial Proteins. 13, 2, p. 527-541 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Effects of ionic liquids on metalloproteins
Patel, A. Y., Jonnalagadda, K. S., Paradis, N., Vaden, T. D., Wu, C. & Caputo, G. A., Jan 1 2021, In: Molecules. 26, 2, 514.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Investigation of the Role of Aromatic Residues in the Antimicrobial Peptide BuCATHL4B
Necelis, M. R., Santiago-Ortiz, L. E. & Caputo, G. A., 2021, In: Protein and Peptide Letters. 28, 4, p. 388-402 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations