Claude Krummenacher

  • 3473 Citations
  • 33 h-Index
1993 …2020
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Personal profile

Research interests

Research Expertise:
Virology | Cell biology | Molecular and structural biology

My lab focuses on the interactions between herpes simplex virus (HSV) and its human host. To identify new therapeutic targets, we use molecular and cellular approaches to understand host-virus interactions and responses to infection. We study the mechanism by which HSV binds to cellular receptors in order to design inhibitors of virus entry. We also characterize cellular responses to identify factors involved in susceptibility to HSV infection. Finally, we also are interested in the effects of human saliva on the susceptibility to infection by HSV. This combination of approaches aims at identifying new biomarkers for HSV susceptibility and discovering novel targets for innovative antiviral targets for innovative therapies. We recently interested in identifying and developing new compounds that can inhibit HSV infection and spread.

Honors and Awards:
Joseph and Josephine Rabinowitz Award for Scientific Excellence at the PENN Dental School (2007)
Stephen L Sacks Investigator Award from the American Herpes Foundation (2005)
Frances R Lax Award for Faculty Development at Rowan University (2015)

Member of:
American Society for Microbiology (http://www.asm.org/)
American Association for the Advancement of Science (http://www.aaas.org/)
American Society for Virology (http://www.asv.org)

Fingerprint Dive into the research topics where Claude Krummenacher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Simplexvirus Medicine & Life Sciences
Glycoproteins Medicine & Life Sciences
Human Herpesvirus 1 Medicine & Life Sciences
herpes simplex Agriculture & Biology
Virus Internalization Medicine & Life Sciences
Receptors, Tumor Necrosis Factor, Member 14 Medicine & Life Sciences
Human herpesvirus 1 Agriculture & Biology
glycoproteins Agriculture & Biology

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2020

Research Output 1993 2019

  • 3473 Citations
  • 33 h-Index
  • 47 Article
  • 3 Review article
  • 2 Chapter
  • 1 Editorial

Interaction between nectin-1 and the human natural killer cell receptor CD96

Holmes, V. M., De Motes, C. M., Richards, P. T., Roldan, J., Bhargava, A. K., Orange, J. S. & Krummenacher, C., Feb 1 2019, In : PloS one. 14, 2, e0212443.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cell Receptors
natural killer cells
receptors
cells
Natural Killer Cells

Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1

Zuo, Y., Charles Whitbeck, J., Haila, G. J., Hakim, A. A., Rothlauf, P. W., Eisenberg, R. J., Cohen, G. H. & Krummenacher, C., Jan 1 2019, In : PloS one. 14, 10, e0223299.

Research output: Contribution to journalArticle

Open Access
Human herpesvirus 1
Human Herpesvirus 1
Fibroblasts
saliva
Viruses
5 Citations (Scopus)

Immunization with Fc-based recombinant Epstein-Barr virus gp350 elicits potent neutralizing humoral immune response in a BALB/c mice model

Zhao, B., Zhang, X., Krummenacher, C., Song, S., Gao, L., Zhang, H., Xu, M., Feng, L., Feng, Q., Zeng, M., Xu, Y. & Zeng, Y., May 1 2018, In : Frontiers in Immunology. 9, MAY, 932.

Research output: Contribution to journalArticle

Humoral Immunity
Human Herpesvirus 4
Immunization
Epstein-Barr Virus Infections
Antigens
3 Citations (Scopus)

Role of microvesicles in the spread of herpes simplex virus 1 in oligodendrocytic cells

Bello-Morales, R., Praena, B., de la Nuez, C., Rejas, M. T., Guerra, M., Galán-Ganga, M., Izquierdo, M., Calvo, V., Krummenacher, C. & López-Guerrero, J. A., May 1 2018, In : Journal of Virology. 92, 10, e000088-18.

Research output: Contribution to journalArticle

Human herpesvirus 1
Human Herpesvirus 1
Viruses
viruses
Chinese hamsters
3 Citations (Scopus)

Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts

Bhargava, A. K., Rothlauf, P. W. & Krummenacher, C., Dec 1 2016, In : Virology. 499, p. 267-277 11 p.

Research output: Contribution to journalArticle

Simplexvirus
Glycoproteins
Intercellular Junctions
nectins
Binding Sites