Projects per year
Personal profile
Research interests
Research Expertise:
Virology | Cell biology | Molecular and structural biology
My lab focuses on the interactions between herpes simplex virus (HSV) and its human host. To identify new therapeutic targets, we use molecular and cellular approaches to understand host-virus interactions and responses to infection. We study the mechanism by which HSV binds to cellular receptors in order to design inhibitors of virus entry. We also characterize cellular responses to identify factors involved in susceptibility to HSV infection. Finally, we also are interested in the effects of human saliva on the susceptibility to infection by HSV. This combination of approaches aims at identifying new biomarkers for HSV susceptibility and discovering novel targets for innovative antiviral targets for innovative therapies. We recently interested in identifying and developing new compounds that can inhibit HSV infection and spread.
Honors and Awards:
Joseph and Josephine Rabinowitz Award for Scientific Excellence at the PENN Dental School (2007)
Stephen L Sacks Investigator Award from the American Herpes Foundation (2005)
Frances R Lax Award for Faculty Development at Rowan University (2015)
Member of:
American Society for Microbiology (http://www.asm.org/)
American Association for the Advancement of Science (http://www.aaas.org/)
American Society for Virology (http://www.asv.org)
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Projects
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Adhesion molecules involved in cancer innate immunity
New Jersey Health Foundation, Inc. (NJHF)
2/17/20 → 3/31/21
Project: Other project
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Development of small inhibitors of herpes simplex virus infection.
New Jersey Health Foundation, Inc.
3/1/18 → 2/28/20
Project: Other project
Research output
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A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection
Zhang, X., Zhao, B., Ding, M., Song, S., Kang, Y., Yu, Y., Xu, M., Xiang, T., Gao, L., Feng, Q., Zhao, Q., Zeng, M. S., Krummenacher, C. & Zeng, Y. X., 2020, In: Theranostics. 10, 13, p. 5704-5718 15 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Herpes simplex virus 1 spread in oligodendrocytic cells is highly dependent on MAl proteolipid
López-Guerrero, J. A., de la Nuez, C., Praena, B., Sánchez-León, E., Krummenacher, C. & Bello-Morales, R., Feb 1 2020, In: Journal of virology. 94, 4, e01739-19.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Localization of the interaction site of herpes simplex virus glycoprotein D (gD) on the Membrane Fusion Regulator, gH/gL
Cairns, T. M., Atanasiu, D., Saw, W. T., Lou, H., Charles Whitbeck, J., Ditto, N. T., Bruun, B., Browne, H., Bennett, L., Wu, C., Krummenacher, C., Brooks, B. D., Eisenberg, R. J. & Cohen, G. H., Sep 29 2020, In: Journal of virology. 94, 20, e00983-20.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Interaction between nectin-1 and the human natural killer cell receptor CD96
Holmes, V. M., De Motes, C. M., Richards, P. T., Roldan, J., Bhargava, A. K., Orange, J. S. & Krummenacher, C., Feb 2019, In: PloS one. 14, 2, e0212443.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
Zuo, Y., Charles Whitbeck, J., Haila, G. J., Hakim, A. A., Rothlauf, P. W., Eisenberg, R. J., Cohen, G. H. & Krummenacher, C., Oct 1 2019, In: PloS one. 14, 10, e0223299.Research output: Contribution to journal › Article › peer-review
Open Access