Projects per year
Personal profile
Research interests
Research Expertise:
Virology | Cell biology | Molecular and structural biology
My lab focuses on the interactions between herpes simplex virus (HSV) and its human host. To identify new therapeutic targets, we use molecular and cellular approaches to understand host-virus interactions and responses to infection. We study the mechanism by which HSV binds to cellular receptors in order to design inhibitors of virus entry. We also characterize cellular responses to identify factors involved in susceptibility to HSV infection. Finally, we also are interested in the effects of human saliva on the susceptibility to infection by HSV. This combination of approaches aims at identifying new biomarkers for HSV susceptibility and discovering novel targets for innovative antiviral targets for innovative therapies. We recently interested in identifying and developing new compounds that can inhibit HSV infection and spread.
Honors and Awards:
Joseph and Josephine Rabinowitz Award for Scientific Excellence at the PENN Dental School (2007)
Stephen L Sacks Investigator Award from the American Herpes Foundation (2005)
Frances R Lax Award for Faculty Development at Rowan University (2015)
Member of:
American Society for Microbiology (http://www.asm.org/)
American Association for the Advancement of Science (http://www.aaas.org/)
American Society for Virology (http://www.asv.org)
Education/Academic qualification
Doctor of Philosophy, doctorate, University of Lausanne
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Collaborations and top research areas from the last five years
Projects
- 4 Finished
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Analyzing and developing antiviral compounds from honey bee venom.
Krummenacher, C. (PI)
New Jersey Health Foundation, Inc. (NJHF)
2/15/24 → 2/14/25
Project: Other project
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Developing Broad-Range Antiviral Peptides Against Herpesviruses and Coronaviruses
Krummenacher, C. (PI)
New Jersey Health Foundation, Inc. (NJHF)
2/15/22 → 2/14/23
Project: Other project
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Adhesion molecules involved in cancer innate immunity
Krummenacher, C. (PI)
New Jersey Health Foundation, Inc. (NJHF)
2/17/20 → 3/31/21
Project: Other project
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Development of small inhibitors of herpes simplex virus infection.
Krummenacher, C. (PI)
New Jersey Health Foundation, Inc.
3/1/18 → 2/28/20
Project: Other project
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A cocktail nanovaccine targeting key entry glycoproteins elicits high neutralizing antibody levels against EBV infection
Zhong, L., Zhang, W., Liu, H., Zhang, X., Yang, Z., Wen, Z., Chen, L., Chen, H., Luo, Y., Chen, Y., Feng, Q., Zeng, M. S., Zhao, Q., Liu, L., Krummenacher, C., Zeng, Y. X., Chen, Y., Xu, M. & Zhang, X., Dec 2024, In: Nature communications. 15, 1, 5310.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Neutralizing antibodies against herpesvirus entry complex and fusogen
Zhong, L., Zhang, W., Krummenacher, C., Zhao, Q. & Zhang, X., Apr 2 2024, Neutralizing Antibodies and their Role in Health and Disease. Nova Science Publishers, Inc., p. 93-109 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions
De La Cruz, N. C., Möckel, M., Niehues, H., Rübsam, M., Malter, W., Zinser, M., Krummenacher, C. & Knebel-Mörsdorf, D., Jun 29 2023, In: Journal of virology. 97, 6, p. e0026223Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Neutralizing antibodies against EBV gp42 show potent in vivo protection and define novel epitopes
Wu, Q., Zhong, L., Wei, D., Zhang, W., Hong, J., Kang, Y., Chen, K., Huang, Y., Zheng, Q., Xu, M., Zeng, M. S., Zeng, Y. X., Xia, N., Zhao, Q., Krummenacher, C., Chen, Y. & Zhang, X., 2023, In: Emerging Microbes and Infections. 12, 2, 2245920.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents
Zhong, L., Zhang, W., Krummenacher, C., Chen, Y., Zheng, Q., Zhao, Q., Zeng, M. S., Xia, N., Zeng, Y. X., Xu, M. & Zhang, X., Aug 2023, In: Trends in Microbiology. 31, 8, p. 788-804 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations