Research Output per year
Research Output per year
Personal profile
Research interests
Research Expertise:
Computer-aided Drug Design | Molecular Dynamics Simulation | Molecular Modeling
The long-term goal of my research program is to gain mechanic insights into the structure, dynamics and function of pharmacologically important biomolecules. The insights enable rational drug design using a hierarchical virtual screening protocol including docking, molecular dynamics simulation, and free energy perturbation methods. My current research aims to: 1) develop novel cancer drugs that target DNA/RNA-quadruples, transporter (ABCB1) and kinase (MLK); 2) develop novel analgesic and anti-drug-addiction agents that target G-protein coupled receptors (GPCR) (Dopamine, TAAR1, Opioid) membrane receptors; 3) develop novel anti-virus drugs against herpes virus entry (gD); 4) develop diabetes drug that simultaneously targets inflammation (PPAR).
Honors and Awards:
2010, Travel Award, the IBBI (Isolated Biomolecules and Biomolecular Interactions) conference, Berlin, Germany
2004, Named to the Dean’s list in recognition of Scholastic Excellence, University of Delaware
1999, Excellent Thesis, Xiamen University
Member of:
American Chemical Society (www.acs.org)
Education/Academic qualification
Doctor of Philosophy, doctorate, University of Delaware
Fingerprint
Dive into the research topics where Chun Wu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
-
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
Arba, M., Wahyudi, S. T., Brunt, D. J., Paradis, N. & Wu, C., Feb 2021, In: Computers in Biology and Medicine. 129, 104156.Research output: Contribution to journal › Article › peer-review
-
Analysis of vismodegib resistance in D473G and W535L mutants of SMO receptor and design of novel drug derivatives using molecular dynamics simulations
Liao, S., Floyd, C., Verratti, N., Leung, L. & Wu, C., Mar 1 2020, In: Life Sciences. 244, 117302.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Binding Interactions of Ergotamine and Dihydroergotamine to 5-Hydroxytryptamine Receptor 1B (5-HT1b) Using Molecular Dynamics Simulations and Dynamic Network Analysis
Sullivan, H. J., Tursi, A., Moore, K., Campbell, A., Floyd, C. & Wu, C., Mar 23 2020, In: Journal of chemical information and modeling. 60, 3, p. 1749-1765 17 p.Research output: Contribution to journal › Article › peer-review
-
Binding of agonist WAY-267,464 and antagonist WAY-methylated to oxytocin receptor probed by all-atom molecular dynamics simulations
Uba, A. I., Radicella, C., Readmond, C., Scorese, N., Liao, S., Liu, H. & Wu, C., Jul 1 2020, In: Life Sciences. 252, 117643.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β2Adrenergic Receptor
Kumar, V., Hoag, H., Sader, S., Scorese, N., Liu, H. & Wu, C., Aug 24 2020, In: Journal of chemical information and modeling. 60, 8, p. 4064-4075 12 p.Research output: Contribution to journal › Article › peer-review