Benjamin Carone

Former affiliation
  • 1775 Citations
  • 10 h-Index
20072020

Research output per year

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Personal profile

Research interests

Research Expertise: 
Epigenetics | Genomics | Histone modifications

My research interests are in the field of Epigenetics, which I approach by working to identify the epigenetic marks and molecular mechanisms responsible for causing and maintaining the inheritance of acquired states.

Investigating the capacity of conserved protein catalytic domains to establish and maintain epigenetic modifications in S. cerevisiae with the ultimate goal establishing the causal role of histone packaging in regulating gene expression. 

Specifically, my laboratory has created a suite of fusion proteins using CRISPR technology to target H3K9me to eGFP tagged endogenous S. cerevisiae genes which we interrogate expression levels using qRT-PCR as flow cytometry.

Testing the hypothesis that mammalian spermatic chromatin is highly organized and that this patterning can function to drive Transgenerational Epigenetic Inheritance.  Determining the genome-wide organization of chromatin in germ cells using genomic and bioinformatics approaches.  We are currently working with previously/externally generated datasets but will also be investigating spermatic chromatin in the context of Ctcf mutant mice at Rowan University as this project matures.

Member of:
American Society for Biochemistry and Molecular Biology (www.asbmb.org)
Genetics Society of America (www.genetics-gsa.org)
Sigma Xi (www.sigmaxi.org)

Education/Academic qualification

Doctor of Philosophy, doctorate

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Projects

Research Output

  • 1775 Citations
  • 10 h-Index
  • 16 Article
  • 1 Short survey
  • 1 Review article

Cationic Molecular Umbrellas as Antibacterial Agents with Remarkable Cell-Type Selectivity

Chen, A., Karanastasis, A., Casey, K. R., Necelis, M., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 1 2020, (Accepted/In press) In : ACS Applied Materials and Interfaces.

Research output: Contribution to journalReview article

  • 1 Scopus citations

    NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C

    Boyle, B. R., Melli, S. E., Altreche, R. S., Padron, Z. M., Yousufzai, F. A. K., Kim, S., Vasquez, M. D., Carone, D. M., Carone, B. R. & Soto, I., Aug 3 2020, In : Development (Cambridge). 147, 21

    Research output: Contribution to journalArticle

    Open Access
  • Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells

    Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Sequence and Dispersity Are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s

    Zhou, Z., Ergene, C., Lee, J. Y., Shirley, D. J., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 16 2019, In : ACS Applied Materials and Interfaces. 11, 2, p. 1896-1906 11 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Antimicrobial activity of a porphyrin binding peptide

    Shirley, D. J., Chrom, C. L., Richards, E. A., Carone, B. R. & Caputo, G. A., Jul 2018, In : Peptide Science. 110, 4, e24074.

    Research output: Contribution to journalArticle

  • 4 Scopus citations