Benjamin Carone

Former affiliation
  • 1418 Citations
  • 9 h-Index
20072019
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Personal profile

Research interests

Research Expertise: 
Epigenetics | Genomics | Histone modifications

My research interests are in the field of Epigenetics, which I approach by working to identify the epigenetic marks and molecular mechanisms responsible for causing and maintaining the inheritance of acquired states.

Investigating the capacity of conserved protein catalytic domains to establish and maintain epigenetic modifications in S. cerevisiae with the ultimate goal establishing the causal role of histone packaging in regulating gene expression. 

Specifically, my laboratory has created a suite of fusion proteins using CRISPR technology to target H3K9me to eGFP tagged endogenous S. cerevisiae genes which we interrogate expression levels using qRT-PCR as flow cytometry.

Testing the hypothesis that mammalian spermatic chromatin is highly organized and that this patterning can function to drive Transgenerational Epigenetic Inheritance.  Determining the genome-wide organization of chromatin in germ cells using genomic and bioinformatics approaches.  We are currently working with previously/externally generated datasets but will also be investigating spermatic chromatin in the context of Ctcf mutant mice at Rowan University as this project matures.

Member of:
American Society for Biochemistry and Molecular Biology (www.asbmb.org)
Genetics Society of America (www.genetics-gsa.org)
Sigma Xi (www.sigmaxi.org)

Education/Academic qualification

Doctor of Philosophy, doctorate

Fingerprint Dive into the research topics where Benjamin Carone is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Epigenomics Medicine & Life Sciences
Spermatozoa Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Centromere Medicine & Life Sciences
Methylation Medicine & Life Sciences
Genes Chemical Compounds
Nutrition Chemical Compounds
Mammals Medicine & Life Sciences

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Research Output 2007 2019

  • 1418 Citations
  • 9 h-Index
  • 15 Article
  • 1 Short survey

Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells

Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.

Research output: Contribution to journalArticle

Open Access
Ionic Liquids
Cytotoxicity
Membrane Lipids
Yeast
Permeability

Sequence and Dispersity Are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s

Zhou, Z., Ergene, C., Lee, J. Y., Shirley, D. J., Carone, B., Caputo, G. & Palermo, E. F., Jan 16 2019, In : ACS Applied Materials and Interfaces. 11, 2, p. 1896-1906 11 p.

Research output: Contribution to journalArticle

Peptidomimetics
Thiophenes
Thiophene
Peptides
Chain length
1 Citation (Scopus)

Antimicrobial activity of a porphyrin binding peptide

Shirley, D. J., Chrom, C. L., Richards, E. A., Carone, B. & Caputo, G., Jul 1 2018, In : Peptide Science. 110, 4, e24074.

Research output: Contribution to journalArticle

Porphyrins
Peptides
Hydrophobicity
Membranes
Hydrophobic and Hydrophilic Interactions
5 Citations (Scopus)

Role of cationic side chains in the antimicrobial activity of C18G

Kohn, E. M., Shirley, D. J., Arotsky, L., Picciano, A. M., Ridgway, Z., Urban, M. W., Carone, B. & Caputo, G., Jan 1 2018, In : Molecules. 23, 2, 329.

Research output: Contribution to journalArticle

peptides
Peptides
amino acids
lipids
Membranes
292 Citations (Scopus)

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., Song, L., Carone, B., Ricci, E. P., Li, X. Z., Fauquier, L., Moore, M. J., Sullivan, R., Mello, C. C., Garber, M. & Rando, O. J., Jan 22 2016, In : Science. 351, 6271, p. 391-396 6 p.

Research output: Contribution to journalArticle

Sperm Maturation
Transfer RNA
Fertilization
Spermatozoa
Mammals