Andrea Bottaro

  • 2608 Citations
  • 25 h-Index
1989 …2019

Research output per year

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Article
2018

Differential cellular composition of human palatine and pharyngeal tonsils

Stanisce, L., Sims, E., Hou, C., Koshkareva, Y., Gaughan, J. P., Kuzin, I. & Bottaro, A., Dec 2018, In : Archives of Oral Biology. 96, p. 80-86 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Brief Report: Treatment of Tumor Necrosis Factor–Transgenic Mice With Anti–Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress

Bouta, E. M., Kuzin, I., de Mesy Bentley, K., Wood, R. W., Rahimi, H., Ji, R. C., Ritchlin, C. T., Bottaro, A., Xing, L. & Schwarz, E. M., Jun 2017, In : Arthritis and Rheumatology. 69, 6, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
14 Scopus citations
2016
15 Scopus citations

Increased numbers of CD23+CD21hi Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes

Kuzin, I. I., Kates, S. L., Ju, Y., Zhang, L., Rahimi, H., Wojciechowski, W., Bernstein, S. H., Burack, R., Schwarz, E. M. & Bottaro, A., Jul 1 2016, In : European Journal of Immunology. 46, 7, p. 1752-1757 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes

Kuzin, I. I., Bouta, E. M., Schwarz, E. M. & Bottaro, A., Aug 1 2015, In : Cellular Immunology. 296, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow

Li, J., Ju, Y., Bouta, E. M., Xing, L., Wood, R. W., Kuzin, I., Bottaro, A., Ritchlin, C. T. & Schwarz, E. M., Jan 1 2013, In : Arthritis and Rheumatism. 65, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

CD23 +CD21 highCD1d high B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential

Moshkani, S., Kuzin, I. I., Adewale, F., Jansson, J., Sanz, I., Schwarz, E. M. & Bottaro, A., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5944-5953 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Peroxisome proliferator-activated receptor γ b cell-specific- deficient mice have an impaired antibody response

Ramon, S., Bancos, S., Thatcher, T. H., Murant, T. I., Moshkani, S., Sahler, J. M., Bottaro, A., Sime, P. J. & Phipps, R. P., Nov 15 2012, In : Journal of Immunology. 189, 10, p. 4740-4747 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice

Li, J., Zhou, Q., Wood, R. W., Kuzin, I., Bottaro, A., Ritchlin, C. T., Xing, L. & Schwarz, E. M., Aug 31 2011, In : Arthritis Research and Therapy. 13, 4, R138.

Research output: Contribution to journalArticle

28 Scopus citations

Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor

Kuzin, I., Sun, H., Moshkani, S., Feng, C., Mantalaris, A., Wu, J. H. D. & Bottaro, A., Jun 1 2011, In : Biotechnology and Bioengineering. 108, 6, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

Expanded CD23+/CD21hi B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy

Li, J., Kuzin, I., Moshkani, S., Proulx, S. T., Xing, L., Skrombolas, D., Dunn, R., Sanz, I., Schwarz, E. M. & Bottaro, A., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6142-6150 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells

Altuwaijri, S., Chuang, K. H., Lai, K. P., Lai, J. J., Lin, H. Y., Young, F. M., Bottaro, A., Tsai, M. Y., Zeng, W. P., Chang, H. C., Yeh, S. & Chang, C., Apr 1 2009, In : Molecular Endocrinology. 23, 4, p. 444-453 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation

Kuzin, I. I., Bagaeva, L., Young, F. M. & Bottaro, A., Jan 1 2008, In : Journal of Immunology. 180, 11, p. 7443-7450 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19 ARF gene

Wang, P. Y., Young, F., Chen, C. Y., Stevens, B. M., Neering, S. J., Rossi, R. M., Bushnell, T., Kuzin, I., Heinrich, D., Bottaro, A. & Jordan, C. T., Nov 15 2008, In : Blood. 112, 10, p. 4184-4192 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Leukemia stem cells in a genetically defined murine model of blast-crisis CML

Neering, S. J., Bushnell, T., Sozer, S., Ashton, J., Rossi, R. M., Wang, P. Y., Bell, D. R., Heinrich, D., Bottaro, A. & Jordan, C. T., Oct 1 2007, In : Blood. 110, 7, p. 2578-2585 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development

Marr, S., Morales, H., Bottaro, A., Cooper, M., Flajnik, M. & Robert, J., Nov 15 2007, In : Journal of Immunology. 179, 10, p. 6783-6789 7 p.

Research output: Contribution to journalArticle

48 Scopus citations
2006

Mad1 is a transcriptional repressor of Bcl-6

Lee, S. C., Bottaro, A., Chen, L. & Insel, R. A., May 1 2006, In : Molecular Immunology. 43, 12, p. 1965-1971 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structural phylogenetic analysis of activation-induced deaminase function

Ichikawa, H. T., Sowden, M. P., Torelli, A. T., Bachl, J., Huang, P., Dance, G. S. C., Marr, S. H., Robert, J., Wedekind, J. E., Smith, H. C. & Bottaro, A., Jul 1 2006, In : Journal of Immunology. 177, 1, p. 355-361 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2004

Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation system.

Young, F. M., Pinkert, C. A. & Bottaro, A., 2004, In : Methods in molecular biology (Clifton, N.J.). 271, p. 77-90 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

A new murine model of humoral immunodeficiency specifically affects class switching to T-independent antigens

Kuzin, I. I., Ugine, G. D., Barth, R. K., Shultz, L. D., Nahm, M. H., Young, F. M. & Bottaro, A., Jul 1 2004, In : European Journal of Immunology. 34, 7, p. 1807-1816 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2003

Activation of terminal B cell differentiation by inhibition of histone deacetylation

Lee, S. C., Bottaro, A. & Insel, R. A., May 2003, In : Molecular Immunology. 39, 15, p. 923-932 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Down-regulation of CD20 on B cells upon CD40 activation

Anolik, J., Looney, R. J., Bottaro, A., Sanz, I. & Young, F., Sep 1 2003, In : European Journal of Immunology. 33, 9, p. 2398-2409 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
2001

Tetracyclines inhibit activated B cell function

Kuzin, I. I., Snyder, J. E., Ugine, G. D., Wu, D., Lee, S., Bushnell, T., Insel, R. A., Young, F. M. & Bottaro, A., Jan 1 2001, In : International Immunology. 13, 7, p. 921-931 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2000

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

Borghesani, P. R., Alt, F. W., Bottaro, A., Davidson, L., Aksoy, S., Rathbun, G. A., Roberts, T. M., Swat, W., Segal, R. A. & Gu, Y., Mar 28 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 7, p. 3336-3341 6 p.

Research output: Contribution to journalArticle

148 Scopus citations

Normal isotype switching in B cells lacking the Iμ exon splice donor site: Evidence for multiple Iμ-like germline transcripts

Kuzin, I. I., Ugine, G. D., Wu, D., Young, F., Chen, J. & Bottaro, A., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
1999

A recurrent breakpoint in the most common deletion of the Ig heavy chain locus (del A1-GP-G2-G4-E)

Brusco, A., Saviozzi, S., Cinque, F., Bottaro, A. & DeMarchi, M., Oct 20 1999, In : Journal of Immunology. 163, 8, p. 4392-4398 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients

Wang, Z., Yunis, D., Irigoyen, M., Kitchens, B., Bottaro, A., Alt, F. W. & Alper, C. A., Jun 1999, In : Clinical Immunology. 91, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus

Seidl, K. J., Manis, J. P., Bottaro, A., Zhang, J., Davidson, L., Kisselgof, A., Oettgen, H. & Alt, F. W., Mar 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 6, p. 3000-3005 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
79 Scopus citations

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination

Sakai, E., Bottaro, A. & Alt, F. W., Oct 25 1999, In : International Immunology. 11, 10, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

29 Scopus citations
1998

An expressed neo(r) cassette provides required functions of the I(γ)2b exon for class switching

Seidl, K. J., Bottaro, A., Vo, A., Zhang, J., Davidson, L. & Alt, F. W., Nov 16 1998, In : International Immunology. 10, 11, p. 1683-1692 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers

Manis, J. P., Van Der Stoep, N., Tian, M., Ferrini, R., Davidson, L., Bottaro, A. & Alt, F. W., Oct 19 1998, In : Journal of Experimental Medicine. 188, 8, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

121 Scopus citations

Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the μ locus

Bottaro, A., Young, F., Chen, J., Serwe, M., Sablitzky, F. & Alt, F. W., Jun 29 1998, In : International Immunology. 10, 6, p. 799-806 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Primate immunoglobulin heavy chain constant gamma genes: An hypothesis of their evolution

Brusco, A., Carbonara, A. O., Crovella, S. & Bottaro, A., Jan 1 1998, In : Human Evolution. 13, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
1995

Variability of the immunoglobulin heavy chain constant region locus: a population study

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Plebani, A., Ugazio, A. G., Galanello, R., Guerra, M. G. & Carbonara, A. O., Mar 1 1995, In : Human Genetics. 95, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
1994

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

Cogné, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H. L. & Alt, F. W., Jun 3 1994, In : Cell. 77, 5, p. 737-747 11 p.

Research output: Contribution to journalArticle

223 Scopus citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation

Castigli, E., Alt, F. W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A. K. & Geha, R. S., Dec 6 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 25, p. 12135-12139 5 p.

Research output: Contribution to journalArticle

230 Scopus citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process

Bottaro, A., Lansford, R., Xu, L., Zhang, J., Rothman, P. & Alt, F. W., Feb 1 1994, In : EMBO Journal. 13, 3, p. 665-674 10 p.

Research output: Contribution to journalArticle

184 Scopus citations

Structural and immunologic analysis of gene triplications in the Ig heavy chain constant region locus

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Plebani, A., Ugazio, A. G., Galanello, R., Van Leeuwen, A. M., DeLange, G. G., Depelchin, S. & Carbonara, A. O., Jan 1 1994, In : Journal of Immunology. 152, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Vilidation of IgA1 and IgA2 measurements by a solid-phase immunoradiometric assay in serum and secretions

Depelchin, S., Dehennin, J. P., Bottaro, A., Carbonara, A., Vaerman, J. P. & Sibille, Y., Sep 1 1994, In : International Journal of Clinical & Laboratory Research. 24, 3, p. 154-161 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
1993

A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon

Zhang, J., Bottaro, A., Li, S., Stewart, V. & Alt, F. W., Jan 1 1993, In : EMBO Journal. 12, 9, p. 3529-3537 9 p.

Research output: Contribution to journalArticle

196 Scopus citations

Deletions, duplications and triplications of the IGHC region in different Italian populations

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Delange, G., Van Leewen, A. M., Galanello, R., Plebani, A., Ugazio, A. U., Guerra, M. G. & Carbonara, A. O., Dec 1 1993, In : Immunodeficiency. 4, 1-4, p. 243-244 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Extensive deletion of immunoglobulin heavy chain constant region genes in the absence of recurrent infections: When is IgG subclass deficiency clinically relevant?

Plebani, A., Ugazio, A. G., Meini, A., Ruggeri, L., Negrini, A., Albertini, A., Leibovitz, M., Duse, M., Bottaro, A., Brusco, R., Cariota, U., Boccazzi, C. & Carbonara, A. O., Jun 1993, In : Clinical Immunology and Immunopathology. 68, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Familial clustering of IGHC deletions and duplications: functional and molecular analysis

Bottaro, A., Gallina, R., Brusco, A., Cariota, U., Boccazzi, C., Barilaro, M. R., Plebani, A., Ugazio, A. G., van Leeuwen, A. M., DeLange, G. G., Vaerman, J. P. & Carbonara, A. O., Jan 1 1993, In : Immunogenetics. 37, 5, p. 356-363 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Gene deletion as a cause of associated deficiency of IgA1, IgG2, IgG4 and IgE

Plebani, A., Carbonara, A. O., Bottaro, A., Gallina, R., Boccazzi, C., Crispino, P., Ruggeri, L., Salvioni, F., Duina, M., Negrini, A., Leibovitz, M. & Ugazio, A. G., Dec 1 1993, In : Immunodeficiency. 4, 1-4, p. 245-248 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the J(H) locus

Chen, J., Young, F., Bottaro, A., Stewart, V., Smith, R. K. & Alt, F. W., Jan 1 1993, In : EMBO Journal. 12, 12, p. 4635-4645 11 p.

Research output: Contribution to journalArticle

169 Scopus citations

Rearrangement of immunoglobin heavy chain constant region in Italian population.

Cariota, U., Brusco, A., Boccazzi, C., Gallina, R., Bottaro, A., Galanello, R., Melis, M. A., Cao, A., Plebani, A. & Albertini, A., 1993, In : The Year in immunology. 7, p. 227-230 4 p.

Research output: Contribution to journalArticle

Replacement of germ-line ε promoter by gene targeting alters control of immunoglobulin heavy chain class switching

Xu, L., Gorham, B., Li, S. C., Bottaro, A., Alt, F. W. & Rothman, P., Jan 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 8, p. 3705-3709 5 p.

Research output: Contribution to journalArticle

108 Scopus citations

The influence of gene duplications in the human immunoglobulin heavy chain constant locus on serum levels of immunoglobulin

Rabbani, H., Bottaro, A., Carbonara, A. O., Brusco, A., Cariota, U., Olsson, P. G., Smith, C. I. E. & Hammarstrom, L., Dec 1 1993, In : Immunodeficiency. 4, 1-4, p. 237-241 5 p.

Research output: Contribution to journalArticle

4 Scopus citations