Andrea Bottaro

  • 2529 Citations
  • 25 h-Index
1989 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1989 2018

2018

Differential cellular composition of human palatine and pharyngeal tonsils

Stanisce, L., Sims, E., Hou, C., Koshkareva, Y., Gaughan, J. P., Kuzin, I. & Bottaro, A., Dec 1 2018, In : Archives of Oral Biology. 96, p. 80-86 7 p.

Research output: Contribution to journalArticle

Adenoids
Palatine Tonsil
B-Lymphocytes
Immunoglobulin D
Stromal Cells
2017
7 Citations (Scopus)

Animal models of rheumatoid pain: Experimental systems and insights

Fischer, B. D., Adeyemo, A., O'Leary, M. & Bottaro, A., Jun 30 2017, In : Arthritis Research and Therapy. 19, 1, 146.

Research output: Contribution to journalReview article

Chronic Pain
Arthritis
Animal Models
Pain
Spondylarthropathies
11 Citations (Scopus)

Brief Report: Treatment of Tumor Necrosis Factor–Transgenic Mice With Anti–Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress

Bouta, E. M., Kuzin, I., de Mesy Bentley, K., Wood, R. W., Rahimi, H., Ji, R. C., Ritchlin, C. T., Bottaro, A., Xing, L. & Schwarz, E. M., Jun 1 2017, In : Arthritis and Rheumatology. 69, 6, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

Lymphatic Vessels
Arthritis
Monocytes
Necrosis
Tumor Necrosis Factor-alpha
12 Citations (Scopus)
Sodium Channels
Electrophysiology
Hyperalgesia
Spinal Ganglia
Up-Regulation
2016
12 Citations (Scopus)
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Biomarkers
Prospective Studies
amsonic acid
6 Citations (Scopus)

Increased numbers of CD23+CD21hi Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes

Kuzin, I. I., Kates, S. L., Ju, Y., Zhang, L., Rahimi, H., Wojciechowski, W., Bernstein, S. H., Burack, R., Schwarz, E. M. & Bottaro, A., Jul 1 2016, In : European Journal of Immunology. 46, 7, p. 1752-1757 6 p.

Research output: Contribution to journalArticle

Reactive Arthritis
Rheumatoid Arthritis
B-Lymphocytes
Lymph Nodes
Arthritis
15 Citations (Scopus)

The CD27-CD70 pathway and pathogenesis of autoimmune disease

Han, B. K., Olsen, N. J. & Bottaro, A., Feb 1 2016, In : Seminars in Arthritis and Rheumatism. 45, 4, p. 496-501 6 p.

Research output: Contribution to journalReview article

Autoimmune Diseases
Systemic Lupus Erythematosus
Animal Disease Models
Rheumatoid Arthritis
B-Lymphocytes
2015
3 Citations (Scopus)

TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes

Kuzin, I. I., Bouta, E. M., Schwarz, E. M. & Bottaro, A., Aug 1 2015, In : Cellular Immunology. 296, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Tumor Necrosis Factor-alpha
Lymph Nodes
Rheumatoid Arthritis
Tumor Necrosis Factor Receptors
2013
26 Citations (Scopus)

Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow

Li, J., Ju, Y., Bouta, E. M., Xing, L., Wood, R. W., Kuzin, I., Bottaro, A., Ritchlin, C. T. & Schwarz, E. M., Jan 1 2013, In : Arthritis and Rheumatism. 65, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Arthritis
B-Lymphocytes
Joints
Lymphatic Vessels
2012
12 Citations (Scopus)

CD23 +CD21 highCD1d high B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential

Moshkani, S., Kuzin, I. I., Adewale, F., Jansson, J., Sanz, I., Schwarz, E. M. & Bottaro, A., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 5944-5953 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Lymph Nodes
Antigens
Population
Transgenic Mice
12 Citations (Scopus)

Peroxisome proliferator-activated receptor γ b cell-specific- deficient mice have an impaired antibody response

Ramon, S., Bancos, S., Thatcher, T. H., Murant, T. I., Moshkani, S., Sahler, J. M., Bottaro, A., Sime, P. J. & Phipps, R. P., Nov 15 2012, In : Journal of Immunology. 189, 10, p. 4740-4747 8 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Antibody Formation
B-Lymphocytes
Germinal Center
Plasma Cells
2011
26 Citations (Scopus)

CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice

Li, J., Zhou, Q., Wood, R. W., Kuzin, I., Bottaro, A., Ritchlin, C. T., Xing, L. & Schwarz, E. M., Aug 31 2011, In : Arthritis Research and Therapy. 13, 4, R138.

Research output: Contribution to journalArticle

Transgenic Mice
Arthritis
B-Lymphocytes
Tumor Necrosis Factor-alpha
Lymph Nodes
7 Citations (Scopus)

Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor

Kuzin, I., Sun, H., Moshkani, S., Feng, C., Mantalaris, A., Wu, J. H. D. & Bottaro, A., Jun 1 2011, In : Biotechnology and Bioengineering. 108, 6, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Tissue culture
Bioreactors
Lymphoid Tissue
Cells
Cell culture
2010
50 Citations (Scopus)

Expanded CD23+/CD21hi B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy

Li, J., Kuzin, I., Moshkani, S., Proulx, S. T., Xing, L., Skrombolas, D., Dunn, R., Sanz, I., Schwarz, E. M. & Bottaro, A., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6142-6150 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Arthritis
B-Lymphocytes
Lymph Nodes
Rheumatoid Arthritis
2009
34 Citations (Scopus)

Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells

Altuwaijri, S., Chuang, K. H., Lai, K. P., Lai, J. J., Lin, H. Y., Young, F. M., Bottaro, A., Tsai, M. Y., Zeng, W. P., Chang, H. C., Yeh, S. & Chang, C., Apr 1 2009, In : Molecular Endocrinology. 23, 4, p. 444-453 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Autoimmunity
B-Lymphocytes
Apoptosis
Autoimmune Diseases
2008
4 Citations (Scopus)

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation

Kuzin, I. I., Bagaeva, L., Young, F. M. & Bottaro, A., Jan 1 2008, In : Journal of Immunology. 180, 11, p. 7443-7450 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
V(D)J Recombination
B-Lymphocytes
B-Lymphoid Precursor Cells
Mutation
17 Citations (Scopus)

The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19 ARF gene

Wang, P. Y., Young, F., Chen, C. Y., Stevens, B. M., Neering, S. J., Rossi, R. M., Bushnell, T., Kuzin, I., Heinrich, D., Bottaro, A. & Jordan, C. T., Nov 15 2008, In : Blood. 112, 10, p. 4184-4192 9 p.

Research output: Contribution to journalArticle

Stem cells
B-Lymphoid Precursor Cells
Leukemia
Hematopoietic Stem Cells
Genes
2007
106 Citations (Scopus)

Leukemia stem cells in a genetically defined murine model of blast-crisis CML

Neering, S. J., Bushnell, T., Sozer, S., Ashton, J., Rossi, R. M., Wang, P. Y., Bell, D. R., Heinrich, D., Bottaro, A. & Jordan, C. T., Oct 1 2007, In : Blood. 110, 7, p. 2578-2585 8 p.

Research output: Contribution to journalArticle

Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stem cells
Leukemia
Stem Cells
48 Citations (Scopus)

Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development

Marr, S., Morales, H., Bottaro, A., Cooper, M., Flajnik, M. & Robert, J., Nov 15 2007, In : Journal of Immunology. 179, 10, p. 6783-6789 7 p.

Research output: Contribution to journalArticle

Xenopus laevis
Amphibians
Xenopus
B-Lymphocytes
Antigens
2006
9 Citations (Scopus)

Immunology in the spotlight at the Dover 'Intelligent Design' trial

Bottaro, A., Inlay, M. A. & Matzke, N. J., May 1 2006, In : Nature Immunology. 7, 5, p. 433-435 3 p.

Research output: Contribution to journalComment/debate

Religion and Science
Religious Philosophies
Jurisprudence
Allergy and Immunology
Curriculum
13 Citations (Scopus)

Mad1 is a transcriptional repressor of Bcl-6

Lee, S. C., Bottaro, A., Chen, L. & Insel, R. A., May 1 2006, In : Molecular Immunology. 43, 12, p. 1965-1971 7 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Genetic Promoter Regions
Cell Differentiation
Transcription Factors
Down-Regulation
28 Citations (Scopus)

Structural phylogenetic analysis of activation-induced deaminase function

Ichikawa, H. T., Sowden, M. P., Torelli, A. T., Bachl, J., Huang, P., Dance, G. S. C., Marr, S. H., Robert, J., Wedekind, J. E., Smith, H. C. & Bottaro, A., Jul 1 2006, In : Journal of Immunology. 177, 1, p. 355-361 7 p.

Research output: Contribution to journalArticle

Genetic Recombination
Takifugu
Nuclear Export Signals
AICDA (activation-induced cytidine deaminase)
Chromosomes
2004
7 Citations (Scopus)

Activation induced deaminase: The importance of being specific

Smith, H. C., Bottaro, A., Sowden, M. P. & Wedekind, J. E., Jun 1 2004, In : Trends in Genetics. 20, 6, p. 224-227 4 p.

Research output: Contribution to journalShort survey

DNA
RNA Editing
Cytidine
Deoxycytidine
Immunoglobulin Genes
1 Citation (Scopus)

Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation system.

Young, F. M., Pinkert, C. A. & Bottaro, A., Jan 1 2004, In : Methods in molecular biology (Clifton, N.J.). 271, p. 77-90 14 p.

Research output: Contribution to journalArticle

Blastocyst
Lymphocytes
Embryonic Stem Cells
V(D)J Recombination
Gene Targeting
2 Citations (Scopus)

A new murine model of humoral immunodeficiency specifically affects class switching to T-independent antigens

Kuzin, I. I., Ugine, G. D., Barth, R. K., Shultz, L. D., Nahm, M. H., Young, F. M. & Bottaro, A., Jul 1 2004, In : European Journal of Immunology. 34, 7, p. 1807-1816 10 p.

Research output: Contribution to journalArticle

T Independent Antigens
Immunoglobulin Class Switching
Immunoglobulin G
T-Lymphocytes
Immunoglobulins
2003
45 Citations (Scopus)

Activation of terminal B cell differentiation by inhibition of histone deacetylation

Lee, S. C., Bottaro, A. & Insel, R. A., Jan 1 2003, In : Molecular Immunology. 39, 15, p. 923-932 10 p.

Research output: Contribution to journalArticle

trichostatin A
Histones
Cell Differentiation
B-Lymphocytes
Cycloheximide
43 Citations (Scopus)

Down-regulation of CD20 on B cells upon CD40 activation

Anolik, J., Looney, R. J., Bottaro, A., Sanz, I. & Young, F., Sep 1 2003, In : European Journal of Immunology. 33, 9, p. 2398-2409 12 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Down-Regulation
Calcium Channels
Signal Transduction
Cytoplasmic Vesicles
2001
40 Citations (Scopus)

Tetracyclines inhibit activated B cell function

Kuzin, I. I., Snyder, J. E., Ugine, G. D., Wu, D., Lee, S., Bushnell, T., Insel, R. A., Young, F. M. & Bottaro, A., Jan 1 2001, In : International Immunology. 13, 7, p. 921-931 11 p.

Research output: Contribution to journalArticle

Tetracyclines
Metalloproteases
B-Lymphocytes
Immunoglobulin Class Switching
Doxycycline
2000
145 Citations (Scopus)

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

Borghesani, P. R., Alt, F. W., Bottaro, A., Davidson, L., Aksoy, S., Rathbun, G. A., Roberts, T. M., Swat, W., Segal, R. A. & Gu, Y., Mar 28 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 7, p. 3336-3341 6 p.

Research output: Contribution to journalArticle

Purkinje Cells
Lymphocytes
Ataxia Telangiectasia
Spinocerebellar Degenerations
Cerebellar Diseases
17 Citations (Scopus)

Normal isotype switching in B cells lacking the Iμ exon splice donor site: Evidence for multiple Iμ-like germline transcripts

Kuzin, I. I., Ugine, G. D., Wu, D., Young, F., Chen, J. & Bottaro, A., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1451-1457 7 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
RNA Splice Sites
Exons
B-Lymphocytes
Genetic Recombination
1999
8 Citations (Scopus)

A recurrent breakpoint in the most common deletion of the Ig heavy chain locus (del A1-GP-G2-G4-E)

Brusco, A., Saviozzi, S., Cinque, F., Bottaro, A. & DeMarchi, M., Oct 20 1999, In : Journal of Immunology. 163, 8, p. 4392-4398 7 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
Minisatellite Repeats
Gene Rearrangement
Homologous Recombination
Gene Deletion
30 Citations (Scopus)

Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients

Wang, Z., Yunis, D., Irigoyen, M., Kitchens, B., Bottaro, A., Alt, F. W. & Alper, C. A., Jan 1 1999, In : Clinical Immunology. 91, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Messenger RNA
DNA
B-Lymphocytes
HLA-B8 Antigen
70 Citations (Scopus)

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus

Seidl, K. J., Manis, J. P., Bottaro, A., Zhang, J., Davidson, L., Kisselgof, A., Oettgen, H. & Alt, F. W., Mar 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 6, p. 3000-3005 6 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
Genetic Recombination
Germ Cells
Genes
Insertional Mutagenesis
78 Citations (Scopus)
Matrix Attachment Regions
Immunoglobulin Heavy Chains
Genetic Recombination
Embryonic Stem Cells
B-Lymphocytes
29 Citations (Scopus)

The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination

Sakai, E., Bottaro, A. & Alt, F. W., Oct 25 1999, In : International Immunology. 11, 10, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

Matrix Attachment Regions
Immunoglobulin Heavy Chains
Genetic Recombination
B-Lymphocytes
Internal-External Control
1998
36 Citations (Scopus)

An expressed neo(r) cassette provides required functions of the I(γ)2b exon for class switching

Seidl, K. J., Bottaro, A., Vo, A., Zhang, J., Davidson, L. & Alt, F. W., Nov 16 1998, In : International Immunology. 10, 11, p. 1683-1692 10 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Exons
Genetic Recombination
RNA Splice Sites
B-Lymphocytes
118 Citations (Scopus)

Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers

Manis, J. P., Van Der Stoep, N., Tian, M., Ferrini, R., Davidson, L., Bottaro, A. & Alt, F. W., Oct 19 1998, In : Journal of Experimental Medicine. 188, 8, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Immunoglobulin Heavy Chains
Genetic Recombination
B-Lymphocytes
Insertional Mutagenesis
53 Citations (Scopus)

Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the μ locus

Bottaro, A., Young, F., Chen, J., Serwe, M., Sablitzky, F. & Alt, F. W., Jun 29 1998, In : International Immunology. 10, 6, p. 799-806 8 p.

Research output: Contribution to journalArticle

Matrix Attachment Regions
Immunoglobulin Class Switching
Hybridomas
Genetic Recombination
Switch Genes

Primate immunoglobulin heavy chain constant gamma genes: An hypothesis of their evolution

Brusco, A., Carbonara, A. O., Crovella, S. & Bottaro, A., Jan 1 1998, In : Human Evolution. 13, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

1995
21 Citations (Scopus)

Variability of the immunoglobulin heavy chain constant region locus: a population study

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Plebani, A., Ugazio, A. G., Galanello, R., Guerra, M. G. & Carbonara, A. O., Mar 1 1995, In : Human Genetics. 95, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
varespladib methyl
Haplotypes
Italy
Population
1994
217 Citations (Scopus)

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

Cogné, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H. L. & Alt, F. W., Jun 3 1994, In : Cell. 77, 5, p. 737-747 11 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
Immunoglobulin Class Switching
B-Lymphocytes
Immunoglobulin G
Genes
226 Citations (Scopus)

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation

Castigli, E., Alt, F. W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A. K. & Geha, R. S., Dec 6 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 25, p. 12135-12139 5 p.

Research output: Contribution to journalArticle

Blastocyst
Immunoglobulin Class Switching
Genetic Recombination
CD40 Ligand
B-Lymphocytes
180 Citations (Scopus)

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process

Bottaro, A., Lansford, R., Xu, L., Zhang, J., Rothman, P. & Alt, F. W., Feb 1 1994, In : EMBO Journal. 13, 3, p. 665-674 10 p.

Research output: Contribution to journalArticle

Transcription
Immunoglobulin E
Genetic Recombination
Lipopolysaccharides
Switches
12 Citations (Scopus)

Structural and immunologic analysis of gene triplications in the Ig heavy chain constant region locus

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Plebani, A., Ugazio, A. G., Galanello, R., Van Leeuwen, A. M., DeLange, G. G., Depelchin, S. & Carbonara, A. O., Jan 1 1994, In : Journal of Immunology. 152, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
Haplotypes
Genes
Immunoglobulin Class Switching
Multigene Family
4 Citations (Scopus)

Vilidation of IgA1 and IgA2 measurements by a solid-phase immunoradiometric assay in serum and secretions

Depelchin, S., Dehennin, J. P., Bottaro, A., Carbonara, A., Vaerman, J. P. & Sibille, Y., Sep 1 1994, In : International Journal of Clinical & Laboratory Research. 24, 3, p. 154-161 8 p.

Research output: Contribution to journalArticle

Immunoradiometric Assay
Immunoglobulin A
Assays
Serum
1993
191 Citations (Scopus)

A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon

Zhang, J., Bottaro, A., Li, S., Stewart, V. & Alt, F. W., Jan 1 1993, In : EMBO Journal. 12, 9, p. 3529-3537 9 p.

Research output: Contribution to journalArticle

Lymphocytes
Exons
Transcription
Switches
B-Lymphocytes
3 Citations (Scopus)

Deletions, duplications and triplications of the IGHC region in different Italian populations

Brusco, A., Cariota, U., Bottaro, A., Boccazzi, C., Delange, G., Van Leewen, A. M., Galanello, R., Plebani, A., Ugazio, A. U., Guerra, M. G. & Carbonara, A. O., Dec 1 1993, In : Immunodeficiency. 4, 1-4, p. 243-244 2 p.

Research output: Contribution to journalArticle

Immunoglobulin Constant Regions
Immunoglobulin Heavy Chains
Immunoglobulin Genes
Gene Deletion
Population Genetics
21 Citations (Scopus)

Extensive deletion of immunoglobulin heavy chain constant region genes in the absence of recurrent infections: When is IgG subclass deficiency clinically relevant?

Plebani, A., Ugazio, A. G., Meini, A., Ruggeri, L., Negrini, A., Albertini, A., Leibovitz, M., Duse, M., Bottaro, A., Brusco, R., Cariota, U., Boccazzi, C. & Carbonara, A. O., Jan 1 1993, In : Clinical Immunology and Immunopathology. 68, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

IgG Deficiency
Immunoglobulin Heavy Chains
Immunoglobulin G
Infection
Genes
12 Citations (Scopus)

Familial clustering of IGHC deletions and duplications: functional and molecular analysis

Bottaro, A., Gallina, R., Brusco, A., Cariota, U., Boccazzi, C., Barilaro, M. R., Plebani, A., Ugazio, A. G., van Leeuwen, A. M., DeLange, G. G., Vaerman, J. P. & Carbonara, A. O., Jan 1 1993, In : Immunogenetics. 37, 5, p. 356-363 8 p.

Research output: Contribution to journalArticle

Haplotypes
Cluster Analysis
Immunoglobulin Heavy Chains
Pseudogenes
Gene Duplication
14 Citations (Scopus)

Gene deletion as a cause of associated deficiency of IgA1, IgG2, IgG4 and IgE

Plebani, A., Carbonara, A. O., Bottaro, A., Gallina, R., Boccazzi, C., Crispino, P., Ruggeri, L., Salvioni, F., Duina, M., Negrini, A., Leibovitz, M. & Ugazio, A. G., Dec 1 1993, In : Immunodeficiency. 4, 1-4, p. 245-248 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Constant Regions
IgG Deficiency
IgA Deficiency
Immunoglobulin Heavy Chains
Immunoglobulin Genes